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Reviews in Cardiovascular Medicine  2018, Vol. 19 Issue (1): 13-19     DOI: 10.31083/j.rcm.2018.01.890
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Contribution of ApoCIII to Diabetic Dyslipidemia and Treatment With Volanesorsen
Jun Zhang1, Natalia de Albuquerque Rocha2, *(), Peter A. McCullough1, 3
1 Baylor University Medical Center, Baylor Heart and Vascular Institute, Dallas, TX 621 N. Hall Street, H-030, Dallas, TX 75226. USA
University of Texas Southwestern Medical Center 5323 Harry Hines Blvd, Dallas TX, 75390-8830. USA
Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, TX 621 N. Hall Street, H-030, Dallas, TX 75226. USA
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Abstract:
Diabetic dyslipidemia in type 2 diabetes (T2DM) is characterized by elevated levels of triglycerides (TG), decreased levels of high density lipoprotein-cholesterol (HDL-C), elevated levels of low density lipoprotein-cholesterol (LDLC), and the predominance of small and dense LDL particles (sdLDL). The mechanism underlying diabetic dyslipidemia remains unclear. Insulin resistance is believed to be an important determinant. Mechanisms underlying insulin resistance-induced diabetic dyslipidemia seem to be related to apolipoprotein CIII (ApoCIII), a known inhibitor of lipoprotein lipase. The concentration of very low density lipoprotein1 (VLDL1) with a higher TG content and abundant ApoCIII was found to be significantly elevated in patients with T2DM. Recently, volanesorsen as a promising ApoIII inhibitor was shown to improve the lipid profile in patients with diabetic dyslipidemia. Herein, this paper will review recent advance in pathophysiology of diabetic dyslipidemia and the role of ApoCIII in this condition, with focus on describing a novel drug volanesorsen as potential treatment strategy.
Key words:  Apolipoprotein CIII      type 2 diabetes mellitus      diabetic dyslipidemia      high density lipoprotein-cholesterol      low density lipoprotein-cholesterol      very low density lipoprotein      volanesorsen     
Published:  30 March 2018     
*Corresponding Author(s):  Natalia de Albuquerque Rocha, E-mail: natalia.a.rocha@gmail.com   

Cite this article: 

Jun Zhang, Natalia de Albuquerque Rocha, and Peter A. McCullough. Contribution of ApoCIII to Diabetic Dyslipidemia and Treatment With Volanesorsen. Reviews in Cardiovascular Medicine, 2018, 19(1): 13-19.

URL: 

https://rcm.imrpress.com/EN/10.31083/j.rcm.2018.01.890     OR     https://rcm.imrpress.com/EN/Y2018/V19/I1/13

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