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Reviews in Cardiovascular Medicine  2018, Vol. 19 Issue (3): 89-95     DOI: 10.31083/j.rcm.2018.03.3185
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Baroreflex stimulation for treating resistant hypertension: ready for the prime-time?
Davide Bolignano1, *(), Giuseppe Coppolino2
1 CNR-Institute of Clinical Physiology, Reggio Calabria, 89124, Italy
2 Renal Unit, Department of Health Sciences, "Magna Graecia" University, Catanzaro, 98100, Italy
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The search of alternative methods for improving clinical management and outcomes of individuals affected by resistant hypertension has become a true health priority. In this review, we aimed at providing a timely overview and evidence synthesis on baroreflex activation therapy (BAT) and endovascular baroreflex amplification (EBA), two device-based therapies which rely on the principle of lowering blood pressure by stimulating the carotid baroreflex to decrease the sympathetic and enhance the parasympathetic activity. In resistant forms of arterial hypertension, accruing evidence has confirmed the capacity of these techniques to improve blood pressure control and to reduce the amount of anti-hypertensive therapy at cost of few side effects. Future results from ongoing randomized sham-controlled trials are eagerly awaited to best define the efficacy, safety and durability of effects in the long term before such an invasive approach may be considered as a suitable option in daily clinical practice.
Key words:  Resistant hypertension      baroreflex activation therapy      endovascular baroreflex amplification     
Published:  30 September 2018     
*Corresponding Author(s):  Davide Bolignano, E-mail:   

Cite this article: 

Davide Bolignano, Giuseppe Coppolino. Baroreflex stimulation for treating resistant hypertension: ready for the prime-time?. Reviews in Cardiovascular Medicine, 2018, 19(3): 89-95.

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