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Reviews in Cardiovascular Medicine  2019, Vol. 20 Issue (1): 19-25     DOI: 10.31083/j.rcm.2019.01.3189
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Advances in epigenetic regulation of vascular aging
Jing Jin1, Yufeng Liu2, *(), Lihong Huang1, Hong Tan1
1 Department of Internal Medicine-Cardiovascular, The second hospital of Dalian medical university, Liaoning, 116027, China
2 Department of Medical Affair, The second hospital of Dalian medical university, Dalian City, Liaoning, 116027, China
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Vascular aging is a major risk factor and driver of agerelated cardiovascular diseases (CVD). Atherosclerosis, hypertension, and other CVD lead to vascular dysfunction that involves multiple pathological processes such as oxidative stress, endothelial dysfunction, inflammation, and autophagy. Epigenetics refers to genetic changes that occur when the DNA remains unchanged that include DNA methylation, histone modification, and non-coding RNA. It has been reported that epigenetics plays an effective regulatory role in CVD and affects cardiovascular repair function. Presently, drugs targeting epigenetics have applications in malignant tumors and inflammation. Therefore, exploration of epigenetic mechanisms in vascular aging will allow us to understand the pathogenesis of diseases related to vascular aging. This review focuses on the pathological changes in vascular aging and analyzes the relationship between vascular aging and epigenetics. Additionally, this review focuses on the pathogenesis of vascular aging related diseases from a new perspective in order to develop epigenetic-based treatment strategies for patients with age-related cardiovascular diseases.

Key words:  Vascular aging      epigenetics      endothelial dysfunction      oxidative stress      inflammation     
Published:  30 March 2019     
*Corresponding Author(s):  Yufeng Liu     E-mail:

Cite this article: 

Jing Jin, Yufeng Liu, Lihong Huang, Hong Tan. Advances in epigenetic regulation of vascular aging. Reviews in Cardiovascular Medicine, 2019, 20(1): 19-25.

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Figure 1.  Vascular age-related molecular signaling pathway (Paneni et al., 2015). Aging, especially vascular aging, is associated with several signaling pathways. FOXO, forkhead box O; AMPK, AMPactivated protein kinase; VCAM-1, vascular cell adhesion molecule1; ICAM-1, intercellular adhesion molecule-1; MCP-1, monocyte chemoattractant protein-1; MnSOD, manganese superoxide dismutase; ecSOD, extracellular superoxide dismutase.

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