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Reviews in Cardiovascular Medicine  2020, Vol. 21 Issue (2): 253-261     DOI: 10.31083/j.rcm.2020.02.5104
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Potential roles of GATA binding protein 5 in cardiovascular diseases
Zhi-Peng Song1, Bo Yan2, 3, 4, *()
1Department of Medicine, Shandong University School of Medicine, Jinan, Shandong, 250014, P. R. China
2The Center for Molecular Genetics of Cardiovascular Diseases, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, 272000, P. R. China
3Shandong Provincial Sino-US Cooperation Research Center for Translational Medicine, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, 272000, P. R. China
4Shandong Provincial Key Laboratory of Cardiac Disease Diagnosis and Treatment, Affiliated Hospital of Jining Medical University, Jining Medical University, Jining, Shandong, 272000, P. R. China
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Abstract:
It is known that functional defects of GATA binding protein 5 (GATA5), an important member of GATA transcription factor family, could cause multiple congenital defects. However, the mechanisms of this transcription factor in cardiovascular diseases are still little known. Finding a genetic approach should help with understanding the possible roles of GATA5 in different cardiovascular diseases and purpose it as a possible therapeutic agent. Hence, this review is divided into three chapters to summarize the roles and main regulatory mechanisms of GATA5 in hypertension, arrhythmia and congenital heart disease, respectively. In each chapter, this review firstly introduces the roles of GATA5 mutations, and then discusses the main regulatory mechanisms of GATA5 in the corresponding diseases (Such as the endothelial dysfunction signaling pathway in the chapter of hypertension, GATA5-NaV1.5 signaling pathway in the chapter of arrhythmia, GATA5-HEY2 and GATA5-Nodal signaling pathway in the chapter of congenital heart disease). Additionally, based on these regulatory networks, it is also speculated that abnormal methylation of the GATA5 gene promoter may lead to cardiovascular diseases such as congenital heart disease. This conjecture is proposed to enrich the regulatory networks of GATA5 and provide a theoretical basis for diagnosis and treatment of cardiovascular diseases.
Key words:  GATA5      hypertension      arrhythmia      congenital heart disease     
Submitted:  10 December 2019      Revised:  20 March 2020      Accepted:  30 March 2020      Published:  30 June 2020     
Fund: 
81870279/National Natural Science Foundation of China
*Corresponding Author(s):  Bo Yan     E-mail:  yanbo@mail.jnmc.edu.cn

Cite this article: 

Zhi-Peng Song, Bo Yan. Potential roles of GATA binding protein 5 in cardiovascular diseases. Reviews in Cardiovascular Medicine, 2020, 21(2): 253-261.

URL: 

https://rcm.imrpress.com/EN/10.31083/j.rcm.2020.02.5104     OR     https://rcm.imrpress.com/EN/Y2020/V21/I2/253

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