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Critical complications of COVID-19: A descriptive meta-analysis study |
Kimia Vakili1, Mobina Fathi1, Aiyoub Pezeshgi2, Ashraf Mohamadkhani3, Mohammadreza Hajiesmaeili4, *( ), Mostafa Rezaei-Tavirani5, *( ), Fatemeh Sayehmiri1 |
1Student research committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, 198571743, Tehran, IR Iran 2Faculty of Medicine, Zanjan University of Medical Sciences, 83153-45139, Zanjan, IR Iran 3Digestive Disease Research Center, Tehran University of Medical Sciences, 1411713135, Tehran, IR Iran 4Skull Base Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, 198571743, Tehran, IR Iran 5Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, 198571743, Tehran, IR Iran |
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Abstract:
The coronavirus disease 2019 (COVID-19) is a novel coronavirus infection that has rapidly spread worldwide, causing a pandemic. The main objective of this meta-analysis was to evaluate the prevalence of the most common symptoms and complications of COVID-19. All relevant studies on the clinical complications of COVID-19 have been identified by searching two web databases (i.e., PubMed and Scopus). Afterward, the relevant data were extracted from the selected studies, and then analyzed by the STATA (Version 14) random-effects model. The 30 studies selected for our meta-analysis covered 6,389 infected patients. The prevalence rates of the most common symptoms were as follows: fever: 84.30% (95% CI: 77.13-90.37; I = 97.74%), cough: 63.01% (95% CI: 57.63-68.23; I = 93.73%), dyspnea: 37.16% (95% CI: 27.31-47.57%; I = 98.32%), fatigue: 34.22% (95% CI: 26.29-42.62; I = 97.29%), and diarrhea: 11.47% (95% CI: 6.96-16.87; I = 95.58%). Moreover, the most prevalent complications were found to be acute respiratory distress syndrome (ARDS) with 33.15% (95% CI: 23.35-43.73; I = 98.56%), arrhythmia with 16.64% (95% CI: 9.34-25.5; I = 92.29%), acute cardiac injury with 15.68% (95% CI: 11.1-20.97; I = 92.45%), heart failure with 11.50% (95% CI: 3.45-22.83; I = 89.48%), and acute kidney injury (AKI) with 9.87% (95% CI: 6.18-14.25; I = 95.64%). In this study, we assessed the prevalence of the main clinical complications of COVID-19, and found that following respiratory complications, cardiac and renal complications are the most common clinical complications of COVID-19.
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Submitted: 06 July 2020
Revised: 21 September 2020
Accepted: 25 September 2020
Published: 30 September 2020
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*Corresponding Author(s):
Mohammadreza Hajiesmaeili,Mostafa Rezaei-Tavirani
E-mail: mrhajiesmaeili@sbmu.ac.ir;tavirany@yahoo.com
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