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Reviews in Cardiovascular Medicine  2021, Vol. 22 Issue (2): 489-497     DOI: 10.31083/j.rcm2202056
Special Issue: Contemporary Management of Special Subsets of Acute Coronary Syndromes Patients
Original Research Previous articles | Next articles
Independent predictors of in-hospital and 1-year mortality rates in octogenarians with acute myocardial infarction
Florina Căruntu1, 2, Diana Aurora Bordejevic2, 3, *(), Bogdan Buz1, 2, *(), Alexandru Gheorghiu2, 3, Mirela Cleopatra Tomescu1, 2
1Cardiology Clinic, Timisoara Municipal Clinical Emergency Hospital, 300024 Timișoara, Romania
2Multidisciplinary Heart Research Center, Victor Babeș University of Medicine and Pharmacy, 300041 Timișoara, Romania
3Cardiology Clinic, Timisoara Institute of Cardiovascular Diseases, 300310 Timișoara, Romania
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Older age is known as a negative prognostic parameter in acute myocardial infarction (AMI) patients. In this study, we aimed to explore age-associated differences in treatment protocols, in-hospital and 1-year mortality. This cohort observational study included 277 consecutive AMI patients, separated into 2 groups according to whether their age was ≥80 years or not. We found that group I patients (aged ≥80 years) had a notably lower rate of percutaneous coronary intervention (PCI) performed (P < 0.0001) and a notably higher in-hospital death rate (P < 0.003). The multivariate logistic regression analysis found that three variables were independent predictors of in-hospital mortality: age ≥80 years (P < 0.0001), LVEF <40% (P < 0.0001), and Killip class ≥3 (P < 0.0001). The 1-year death rate was again significantly higher in group I patients (P < 0.001) and was independently predicted by the triple-vessel coronary artery disease (P = 0.004) and an LVEF <40% at admission (P = 0.001). The 1-year readmission rate was superior in group I (P < 0.01) and independently predicted by an age ≥80 years (P < 0.001), and an history of congestive heart failure (P < 0.0001) or permanent atrial fibrillation (P < 0.001). We concluded that patients aged ≥80 benefit less often from a PCI and have higher rates of in-hospital mortality, as well as of 1-year readmission and mortality rates.
Key words:  Acute myocardial infarction      Age ≥80 years      Treatment      Prognosis     
Submitted:  21 February 2021      Revised:  22 April 2021      Accepted:  21 May 2021      Published:  30 June 2021     
*Corresponding Author(s): (Diana Aurora Bordejevic); (Bogdan Buz)   

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Florina Căruntu, Diana Aurora Bordejevic, Bogdan Buz, Alexandru Gheorghiu, Mirela Cleopatra Tomescu. Independent predictors of in-hospital and 1-year mortality rates in octogenarians with acute myocardial infarction. Reviews in Cardiovascular Medicine, 2021, 22(2): 489-497.

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