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Reviews in Cardiovascular Medicine  2021, Vol. 22 Issue (2): 531-536     DOI: 10.31083/j.rcm2202061
Special Issue: State-of-the-Art Cardiovascular Medicine in Asia 2021
Original Research Previous articles | Next articles
Lipocalin 2: could it be a new biomarker in pediatric pulmonary hypertension associated with congenital heart disease?
Hongju Zhang1, Tao Sun2, Jiao Yang1, Yan Sun1, Guowen Liu1, Chayakrit Krittanawong3, Edward A. El-Am4, Rody G. Bou Chaaya4, Liyuan Xu1, Zankai Ye5, Zhiqiang Li5, Ning Ma1, *()
1Department of Echocardiography, Capital Medical University, Beijing Children's Hospital, National Center for Children's Health, 100045 Beijing, China
2Division of Cardiology, Capital Medical University, Beijing Anzhen Hospital, 100045 Beijing, China
3Section of Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
4Department of Medicine, Indiana University School of Medicine, Indianapolis, IN 46617, USA
5Department of Cardiac Surgery, Capital Medical University, Beijing Children's Hospital, National Center for Children's Health, 100045 Beijing, China
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Abstract:
The role of lipocalin 2 (LCN2) in pulmonary hypertension (PH) in pediatric patients with congenital heart disease (CHD) remains unclear. We sought to investigate whether LCN2 could be a potential biomarker for PH in pediatric patients who underwent surgery for CHD. From December 2018 to February 2020, patients undergoing surgical repair for congenital defects with and without PH were identified. Healthy children without CHD and PH served as controls. A mean pulmonary artery pressure (mPAP) >20 mmHg was used as the definition of PH. Blood samples and echocardiograms were obtained in all patients and right heart catheterization was performed in 79 patients. Multivariable logistic regression analysis was used to determine potential predictors for PH. Among 102 patients, the median age was 10 [Interquartile range (IQR) 7.0–13] months, and 37.5% were female. Compared to non-PH patients and controls, PH patients showed elevated levels of LCN2 (P < 0.001). In addition, LCN2 levels positively correlated with the invasive haemodynamic indices of PH. In univariate regression, LCN2 (odds ratio = 2.69 [1.06–5.31], P < 0.001), N-Terminal pro Brain Natriuretic Peptide (NT-proBNP) (OR = 1.91 [1.21–7.56], P = 0.03) and high-sensitive troponin T (hsTnT) (OR = 1.36 [1.01–3.57], P = 0.01) were associated with PH; however, only LCN2 (OR = 1.68 [1.04–4.52], P = 0.03) was significantly associated with PH on multivariate analysis. In conclusion, children with PH had increased LCN2 expression. LCN2 levels positively correlated with invasive indices of PH. These results indicate LCN2 could be a useful biomarker for prediction of PH in pediatric CHD cases.
Key words:  Congenital heart disease      Pulmonary hypertension      Lipocalin 2      Biomarkers     
Submitted:  07 April 2021      Revised:  28 May 2021      Accepted:  10 June 2021      Published:  30 June 2021     
Fund: 
719062/Natural Science Foundation of Beijing Municipality
7202046/Natural Science Foundation of Beijing Municipality
81641071/National Natural Science Foundation of China
*Corresponding Author(s):  Ning Ma     E-mail:  maning_echo@163.com

Cite this article: 

Hongju Zhang, Tao Sun, Jiao Yang, Yan Sun, Guowen Liu, Chayakrit Krittanawong, Edward A. El-Am, Rody G. Bou Chaaya, Liyuan Xu, Zankai Ye, Zhiqiang Li, Ning Ma. Lipocalin 2: could it be a new biomarker in pediatric pulmonary hypertension associated with congenital heart disease?. Reviews in Cardiovascular Medicine, 2021, 22(2): 531-536.

URL: 

https://rcm.imrpress.com/EN/10.31083/j.rcm2202061     OR     https://rcm.imrpress.com/EN/Y2021/V22/I2/531

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