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Reviews in Cardiovascular Medicine  2021, Vol. 22 Issue (3): 769-777     DOI: 10.31083/j.rcm2203083
Special Issue: State-of-the-Art Cardiovascular Medicine in Asia 2021
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Role of the ACE2/Ang-(1-7)/Mas axis in glucose metabolism
Shiyuan Zhao1, Wenxue Sun1, Pei Jiang1, 2, *()
1Department of Clinical Pharmacy, Jining First People's Hospital, Jining Medical University, 272000 Jining, Shandong, China
2Department of Clinical & Translational Medicine, Jining Life Science Center, 272000 Jining, Shandong, China
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The renin-angiotensin system (RAS) helps to regulate cardiovascular function, the maintenance of electrolyte and fluid balance, and blood pressure. The RAS contains two axes; the angiotensin-converting enzyme/angiotensin II/Ang II type 1 receptors (ACE/Ang II/AT1) classic axis, which has a role in regulating blood pressure, vascular oxidative stress, coagulation, and cellular proliferation. The other is the angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas receptors (ACE2/Ang-(1-7)/Mas) axis, which can inhibit the former axis, improve fat metabolism, reduce inflammation and oxidative stress, and enhance glucose tolerance and insulin sensitivity. The ACE2/Ang-(1-7)/Mas axis is found in blood vessels, kidneys, liver, pancreas and the brain. It can protect the body from abnormalities in glucose metabolism. The ACE2/Ang-(1-7)/Mas axis can enhance glucose tolerance and improve insulin sensitivity by protecting pancreatic β cells, increasing insulin secretion, improving glucose metabolism in adipose tissue, enhancing glucose uptake by skeletal muscle, and inhibiting hepatic gluconeogenesis. This article reviews the main characteristics and functions of the ACE2/Ang-(1-7)/Mas axis and its regulation of glucose metabolism in order to demonstrate its potential as a target for the treatment of metabolic diseases such as diabetes.
Key words:  ACE2/Ang-(1-7)/Mas axis      Glucose metabolism      Renin-angiotensin system      Pancreatic β cells      Insulin resistance      Diabetes     
Submitted:  23 June 2021      Revised:  27 July 2021      Accepted:  09 August 2021      Published:  24 September 2021     
81602846/National Natural Science Foundation of China
tsqn201812159/Taishan Scholar Project of Shandong Province
2019SMNS012/Key Research and Development Program of Jining Science and Technology
*Corresponding Author(s):  Pei Jiang     E-mail:

Cite this article: 

Shiyuan Zhao, Wenxue Sun, Pei Jiang. Role of the ACE2/Ang-(1-7)/Mas axis in glucose metabolism. Reviews in Cardiovascular Medicine, 2021, 22(3): 769-777.

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