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Reviews in Cardiovascular Medicine  2021, Vol. 22 Issue (3): 817-834     DOI: 10.31083/j.rcm2203088
Special Issue: Diet, nutrients and cardiovascular disease prevention
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Dyslipidemia in pediatrician's practice
Alla V. Burlutskaya1, Victoria E. Tril1, *(), Lily V. Polischuk2, Vladimir M. Pokrovskii3, *()
1Department of Pediatrics №2, Kuban State Medical University, 350063 Krasnodar, Russia
2Department of Therapy №2, Kuban State Medical University, 350063 Krasnodar, Russia
3Department of Normal Physiology, Kuban State Medical University, 350063 Krasnodar, Russia
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Abstract:
Atherosclerosis ranks first among cardiovascular system diseases. It is the "disease of the century", and more than 50% of people with circulatory pathology die of it. The clinical manifestation of atherosclerosis is observed at the middle and older ages, but it is known that the pathological process develops much earlier. There has been a clear trend in theoretical and practical cardiology in recent years to study the earliest atherogenic markers. Epidemiological, clinical, and morphological studies have proved the presence in children and adolescents of sexual, endogenous, exogenous, primary, and potentiating risk factors contributing to an early formation of a pathogenic foundation for atherosclerotic cardiovascular diseases. Disorders of lipid metabolism – dyslipidemias are attributed to the most significant risk factor for atherosclerotic cardiovascular diseases. The DLP prevalence in the pediatric population is extremely high. According to the results of conducted global studies, lipid metabolism disorders occur in more than 70% of children and adolescents. It causes the need for timely diagnostic, therapeutic and preventive measures. The need to extrapolate the risk factor concept to childhood age is justified by several reasons, the main of which include the broadest spread of atherosclerosis that has become a global pandemic, genetic determinism, and low variability of the lipid spectrum of blood serum: the levels of lipids and lipoproteins discovered in childhood are stable throughout life and have an independent prognostic value. That is why the most practical significance is inherent to the study of lipid and lipoprotein metabolism, starting in the early periods of lipid and lipoprotein ontogenesis. Since risk factors can be identified at the preclinical stage of the atherosclerotic process, dyslipidemia phenotyping will facilitate identifying children and adolescents at risk of developing cardiovascular pathologies in the future. The study objective is to examine the pathophysiological aspects of lipid and lipoprotein metabolism and examine DLP epidemiology – as the leading atherosclerotic cardiovascular disease risk factor in children and adolescents, DLP classification, modern approaches to DLP diagnosis and management.
Key words:  Children      Adolescents      Risk factors      Atherosclerosis      Dyslipidemia     
Submitted:  22 April 2021      Revised:  02 July 2021      Accepted:  05 July 2021      Published:  24 September 2021     
*Corresponding Author(s):  v.tril@mail.ru (Victoria E. Tril); pokrovskyvm@gmail.com (Vladimir M. Pokrovskii)   

Cite this article: 

Alla V. Burlutskaya, Victoria E. Tril, Lily V. Polischuk, Vladimir M. Pokrovskii. Dyslipidemia in pediatrician's practice. Reviews in Cardiovascular Medicine, 2021, 22(3): 817-834.

URL: 

https://rcm.imrpress.com/EN/10.31083/j.rcm2203088     OR     https://rcm.imrpress.com/EN/Y2021/V22/I3/817

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