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Reviews in Cardiovascular Medicine  2021, Vol. 22 Issue (3): 895-901     DOI: 10.31083/j.rcm2203096
Special Issue: State-of-the-Art Cardiovascular Medicine in Asia 2021
Original Research Previous articles | Next articles
Association of polymorphisms in endothelial dysfunction-related genes with susceptibility to essential hypertension in elderly Han population in Liaoning province, China
Na Ta1, †, Mengwei Liu1, †, Yue Wang1, Fanxin Zeng1, Fangfang Nie1, Mengke Shang1, Xiaotong Wang1, Yuetian Yang1, Man Liang1, Lu Wen1, Lanxin Ou1, Zhibin Yang1, Wanyang Liu1, *(), Xiuping Liu1, 2, *()
1Department of Nutrition and Food Hygiene, School of Public Health, China Medical University, 110122 Shenyang, Liaoning, China
2Department of Nursing, Shengjing Hospital of China Medical University, 110004 Shenyang, Liaoning, China
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Abstract:
Hypertension is a complex disease which is mainly influenced by genetic factors. Recently, genome-wide association study (GWAS) found three novel endothelial dysfunction-related sites: Vascular endothelial growth factor A (VEGFA) rs9472135, Faciogenital dysplasia 5 (FGD5) rs11128722, Zinc Finger C3HC-type Containing 1 (ZC3HC1) rs11556924. Endothelial dysfunction is one of the early events in pathophysiology of essential hypertension. To investigate the association of endothelial dysfunction-related genes with essential hypertension, we conducted a case-control study of 431 patients with hypertension and 345 controls. The polymorphisms were detected using Taqman Probe. The alleles and genotypes of ZC3HC1 rs11556924 and VEGFA rs9472135 were not statistically different between the two groups, while the allele of FGD5 rs11128722 was different [P = 0.045, OR = 1.265, 95% CI = (1.009–1.586)], especially in the male [P = 0.035, OR = 1.496, 95% CI = (1.037–2.158)]. Analyzing the different of genotype distribution of 3 SNPs in the two groups under different genetic models, the genotypes of FGD5 rs11128722 showed difference in male under dominant model [P = 0.049, OR = 1.610, 95% CI = (1.018–2.544)]. The polymorphism of FGD5 rs11128722 had a significant difference in Body Mass Index (BMI) among different genotypes; In the additive genetic model, BMI of GA genotype was higher than that of GG (P = 0.038); GA + AA was higher than GG in the dominant genetic model (P = 0.011). In our study, we found that the polymorphisms of VEGFA rs9472135 and ZC3HC1 rs11556924 may not significantly associated with the risk of essential hypertension, and FGD5 rs11128722 may increase the risk of it, especially in elderly men.
Key words:  Essential hypertension      Polymorphism      Vascular endothelial dysfunction     
Submitted:  08 April 2021      Revised:  02 June 2021      Accepted:  21 June 2021      Published:  24 September 2021     
Fund: 
81573240/National Natural Science Foundation of China
*Corresponding Author(s):  wyliu@cmu.edu.cn (Wanyang Liu); liuxp@sj-hospital.org (Xiuping Liu)   
About author:  These authors contributed equally.

Cite this article: 

Na Ta, Mengwei Liu, Yue Wang, Fanxin Zeng, Fangfang Nie, Mengke Shang, Xiaotong Wang, Yuetian Yang, Man Liang, Lu Wen, Lanxin Ou, Zhibin Yang, Wanyang Liu, Xiuping Liu. Association of polymorphisms in endothelial dysfunction-related genes with susceptibility to essential hypertension in elderly Han population in Liaoning province, China. Reviews in Cardiovascular Medicine, 2021, 22(3): 895-901.

URL: 

https://rcm.imrpress.com/EN/10.31083/j.rcm2203096     OR     https://rcm.imrpress.com/EN/Y2021/V22/I3/895

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