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Reviews in Cardiovascular Medicine  2021, Vol. 22 Issue (3): 947-958     DOI: 10.31083/j.rcm2203103
Special Issue: State-of-the-Art Cardiovascular Medicine in Asia 2021
Original Research Previous articles | Next articles
Abnormal expression of TGFBR2, EGF, LRP10, and IQGAP1 is involved in the pathogenesis of coronary artery disease
Yanwei Du1, 2, †, Yanan Hu2, †, Naiyan Wen3, Shuang Fu2, Guorong Zhang2, Li Li2, Tiantian Liu2, Xuejiao Lv1, *(), Wenfeng Zhang2, *()
1Department of Respiratory and Critical Care Medicine, the 2nd Hospital of Jilin University, 130041 Changchun, Jilin, China
2Department of Prescriptions, Pathology and Pathophysiology, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China
3Department of Nursing, Changchun University of Chinese Medicine, 130117 Changchun, Jilin, China
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Abstract:
Coronary artery disease (CAD) is the most common cardiovascular disease worldwide. In this study, we investigated the pathogenesis of CAD. We downloaded the GSE98583 dataset, including 12 CAD samples and 6 normal samples, from the Gene Expression Omnibus (GEO) database and screened differentially expressed genes (DEGs) in CAD versus normal samples. Next, we performed functional enrichment analysis, protein-protein interaction (PPI) network, and functional module analyses to explore potential functions and regulatory functions of identified DEGs. Next, transcription factors (TFs) and microRNAs (miRNAs) targeting DEGs were predicted. In total, 456 DEGs were identified in CAD and normal samples, including 175 upregulated and 281 downregulated genes. These genes were enriched in the intestinal immune network for immunoglobulin A production and the mitogen-activated protein kinase signaling pathway (e.g., TGFBR2 and EGF). The PPI network contained 212 genes, and HIST1H2BJ, HIST1H2AC, EGF, and EP300 were hub genes with degrees higher than 10. Four significant modules were identified from the PPI network, with genes in the modules mainly enriched in the inflammatory response, protein ubiquitination involved in ubiquitin-dependent protein catabolic processes, protein transport, and mitochondrial translational elongation, respectively. Two TFs (E2F1 and FOXK1) and five miRNAs (miR-122A, miR-516-5P, miR-507, miR-342, and miR-520F) were predicted to target 112 DEGs. miR-122A reportedly targets both LRP10 and IQGAP1 in the TF-miRNA target regulatory network. The abnormal expression of TGFBR2, EGF, LRP10, and IQGAP1 may be implicated in CAD pathogenesis. Our study provides targets and potential regulators for investigating CAD pathogenesis.
Key words:  Coronary artery disease      Transcription factor      microRNAs      MAPK signaling pathway      Pathogenesis     
Submitted:  22 February 2021      Revised:  14 April 2021      Accepted:  15 July 2021      Published:  24 September 2021     
Fund: 
81600207/National Natural Science Foundation of China
20190103090JH/Excellent Youth Fund of Jilin Provincial Science and Technology Department
JJKH20200898KJ/"13th five year plan" science and technology research project of Jilin Provincial Department of Education
20190304054YY/Science and Technology Department of Jilin Province
2019RS01/"Xinglin scholar project" of Changchun University of traditional Chinese Medicine
2018KJ01/College Project Grant
*Corresponding Author(s):  wenfzh@163.com (Wenfeng Zhang); lvxuejiao0311@163.com (Xuejiao Lv)   
About author:  These authors contributed equally.

Cite this article: 

Yanwei Du, Yanan Hu, Naiyan Wen, Shuang Fu, Guorong Zhang, Li Li, Tiantian Liu, Xuejiao Lv, Wenfeng Zhang. Abnormal expression of TGFBR2, EGF, LRP10, and IQGAP1 is involved in the pathogenesis of coronary artery disease. Reviews in Cardiovascular Medicine, 2021, 22(3): 947-958.

URL: 

https://rcm.imrpress.com/EN/10.31083/j.rcm2203103     OR     https://rcm.imrpress.com/EN/Y2021/V22/I3/947

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