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Reviews in Cardiovascular Medicine  2021, Vol. 22 Issue (3): 959-966     DOI: 10.31083/j.rcm2203104
Special Issue: Arterial stiffness in cardiovascular disease
Original Research Previous articles | Next articles
Evaluation of the aortic velocity propagation, epicardial fat thickness, and carotid intima-media thickness in patients with subclinical hypothyroidism
Emin Asoğlu1, *(), Tayyar Akbulut2, Zeki Doğan3, Ramazan Asoğlu4
1Cardiology Department, Mardin Community Hospital, 47100 Mardin, Turkey
2Cardiology Department, Van Training and Research Hospital,65040 Van, Turkey
3Department of Cardiology, Medicine Hospital, Istanbul Atlas University, 34403 Istanbul, Turkey
4Cardiology Department, Adıyaman University Training and Research Hospital, 02040 Adıyaman, Turkey
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Subclinical hypothyroidism (SH) is associated with hemodynamic and metabolic abnormalities that cause endothelial dysfunction and atherosclerotic cardiovascular diseases. Aortic velocity propagation (AVP), epicardial fat thickness (EFT), and carotid intima-media thickness (CIMT) may provide additional information in SH patients. This study aimed to evaluate thyroid stimulating hormone (TSH), AVP, EFT, and CIMT in SH patients, and determine the associations among these parameters. Eighty patients with SH and 43 euthyroid (EU) individuals were enrolled. Blood samples were collected to measure laboratory parameters. Patients were divided into two groups based on their TSH values (TSH ≥10 or TSH <10 mIU/L). AVP, EFT, and CIMT were measured and compared between the study groups. A multivariate linear regression model was used for analysis of the independent predictors of AVP (beta = –0.298; 95% confidence interval = –0.946 to –0.287; p < 0.001). AVP was significantly lower in SH patients than the control group (43.7 ± 12.5 and 62.6 ± 13.8, respectively; p < 0.001). EFT values were similar between the SH and control groups (0.7 ± 0.3 and 0.6 ± 0.2, respectively; p = 0.10). SH patients had higher CIMT values than the control group (0.8 ± 0.3 and 0.5 ± 0.2, respectively; p < 0.001). In the multivariate linear analysis, TSH was an independent predictor of AVP. AVP was lower and CIMT was higher in SH patients compared to EU individuals. The increased CIMT and decreased AVP levels were significantly associated with TSH levels in SH patients.
Key words:  Subclinical hypothyroidism      Aortic velocity propagation      Epicardial fat thickness      Carotid intima-media thickness     
Submitted:  29 April 2021      Revised:  26 June 2021      Accepted:  16 July 2021      Published:  24 September 2021     
*Corresponding Author(s):  Emin Asoğlu     E-mail:

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Emin Asoğlu, Tayyar Akbulut, Zeki Doğan, Ramazan Asoğlu. Evaluation of the aortic velocity propagation, epicardial fat thickness, and carotid intima-media thickness in patients with subclinical hypothyroidism. Reviews in Cardiovascular Medicine, 2021, 22(3): 959-966.

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