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Reviews in Cardiovascular Medicine  2021, Vol. 22 Issue (3): 967-973     DOI: 10.31083/j.rcm2203105
Special Issue: State-of-the-Art Cardiovascular Medicine in Asia 2021
Original Research Previous articles | Next articles
Validity of SOFA score as a prognostic tool for critically ill elderly patients with acute infective endocarditis
Yaowang Lin1, Feng Liu1, Shuying Gong1, Bihong Liao1, Huadong Liu1, Jie Yuan1, Danqing Yu2, Haiyan Qin3, Meishan Wu1, *(), Shaohong Dong1, *()
1Department of Cardiology, Shenzhen Cardiovascular Minimally Invasive Medical Engineering Technology Research and Development Center, Shenzhen People's Hospital (The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology), 518020 Shenzhen, Guangdong, China
2Department of Cardiology, Guangdong General Hospital, Guangdong Academy of Sciences, 510650 Guangzhou, Guangdong, China
3Department of Health Management, Shenzhen People's Hospital, 518020 Shenzhen, Guangdong, China
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The prognostic value of the sequential organ failure assessment (SOFA) score for critically ill elderly patients with acute infective endocarditis (IE) remains unknown. From January 2015 to December 2019, 111 elderly (≥65 years) patients with acute IE were consecutively included and divided into a low SOFA (<6) group (n = 71) and a high SOFA (≥6) group (n = 40). Endpoints included in-hospital and long-term (12–36 month) mortality. A high SOFA score was related to higher incidence of in-hospital mortality (30.0%) with an area under the curve (AUC) of 0.796. In multivariate analysis, age [odds ratio (OR) = 2.21, 95% confidence intervals (CI), 1.16–6.79, p = 0.040], SOFA ≥6 (OR = 6.38, 95% CI, 1.80–16.89, p = 0.004) and surgical treatment (OR = 0.21, 95% CI, 0.05–0.80, p = 0.021) were predictive of in-hospital mortality. A Cox proportional-hazards model identified age [Hazard ratios (HR)= 2.85, 95% CI, 1.11–7.37, p = 0.031], diabetes mellitus (HR = 3.99, 95% CI, 1.35–11.80, p = 0.013), SOFA ≥6 (OR = 3.38, 95% CI, 1.26–9.08, p = 0.001) and surgical treatment (HR = 0.24, 95% CI, 0.08–0.68, p = 0.021) as predictors of long-term mortality. A high SOFA score predicts a poor outcome including in-hospital and long-term mortality in critically ill elderly patients with acute IE.
Key words:  SOFA      Elderly patients      Acute infective endocarditis      In-hospital mortality      Long-term mortality     
Submitted:  17 May 2021      Revised:  20 July 2021      Accepted:  21 July 2021      Published:  24 September 2021     
SZXK003/Shenzhen Key Medical Discipline Construction Fund
SZSM201412012/Sanming Project of Medicine in Shenzhen
*Corresponding Author(s): (Meishan Wu); (Shaohong Dong)   

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Yaowang Lin, Feng Liu, Shuying Gong, Bihong Liao, Huadong Liu, Jie Yuan, Danqing Yu, Haiyan Qin, Meishan Wu, Shaohong Dong. Validity of SOFA score as a prognostic tool for critically ill elderly patients with acute infective endocarditis. Reviews in Cardiovascular Medicine, 2021, 22(3): 967-973.

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[1] Yaowang Lin, Yang Chen, Jie Yuan, Xinli Pang, Huadong Liu, Shaohong Dong, Qiuling Chen. Intravenous morphine use in acute heart failure increases adverse outcomes: a meta-analysis[J]. Reviews in Cardiovascular Medicine, 2021, 22(3): 865-872.
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