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Reviews in Cardiovascular Medicine  2014, Vol. 15 Issue (S1): 9-20     DOI: 10.3908.ricm15S1S004
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Highly Active Antiretroviral Therapy–related Mechanisms of Endothelial and Platelet Function Alterations
Paolo Gresele1, Emanuela Falcinelli1, Stefania Momi1, Daniela Francisci2, Franco Baldelli2
1 Division of Internal and Cardiovascular Medicine, Department of Medicine, University of Perugia, Perugia, Italy
2 Division of Infectious Disease, Department of Medicine, University of Perugia, Perugia, Italy
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Abstract:
Highly active antiretroviral therapy (HAART) has transformed human immunodeficiency virus (HIV) infection into a chronic condition, which has allowed the infected population to age and become prone to chronic degenerative diseases common to the general population, including atherosclerotic cardiovascular disease, and coronary artery disease (CAD). Possible causative mechanisms of HIV-associated CAD are related to classic cardiovascular risk factors, such as dyslipidemia, insulin resistance, and fat redistribution, which may be due to either HIV infection or to HAART-associated toxicity. However, other mechanisms are emerging as crucial for the cardiovascular complication of HIV and HAART. This article analyzes the effects of HIV and HAART on endothelial function, endothelium-leukocyte interactions, and platelets as possible mechanisms of enhanced cardiovascular risk.
Key words:  Human immunodeficiency virus      Coronary artery disease      Highly active antiretroviral therapy      Platelet reactivity      Inflammation     
Published:  20 January 2014     

Cite this article: 

Paolo Gresele, Emanuela Falcinelli, Stefania Momi, Daniela Francisci, Franco Baldelli. Highly Active Antiretroviral Therapy–related Mechanisms of Endothelial and Platelet Function Alterations. Reviews in Cardiovascular Medicine, 2014, 15(S1): 9-20.

URL: 

https://rcm.imrpress.com/EN/10.3908.ricm15S1S004     OR     https://rcm.imrpress.com/EN/Y2014/V15/IS1/9

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