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Reviews in Cardiovascular Medicine  2014, Vol. 15 Issue (3): 197-207     DOI: 10.3909/ricm0726
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Utilization of Galectin-3 in Case Management Across the Spectrum of Heart Failure
Peter McCullough1, Rudolph A. de Boer2, Frank Edelmann3, Connie M. Lewis4, Alan S. Maisel5
1 Baylor University Medical Center, Baylor Heart and Vascular Institute, Baylor Jack and Jane Hamilton Heart and Vascular Hosital, Dallas, TX, The Heart Hospital, Plano TX
2 Department of Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
3 Department of Cardiology, University of Göttingen, German Center for Cardiovascular Research, Göttingen Division of Cardiology, Germany
4 Department of Medicine, Vanderbilt University Medical Center, Nashville, TN
5 San Diego Veterans Affairs Medical Center, San Diego, CA
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In patients with heart failure as a result of mechanical and neurohormonal derangements, macrophages secrete galectin-3, which is a paracrine and endocrine factor that stimulates additional macrophages, pericytes, myofibroblasts, and fibroblasts to proliferate and secrete procollagen I, which is irreversibly crosslinked to form fibrotic collagen. Normal plasma concentrations of galectin-3 are < 11.0 ng/mL. Galectin-3 measured in blood has been shown to predict the development of all-cause mortality and heart failure in the general population, identify increased risk for de novo heart failure and progressive loss of renal filtration function in healthy middle-aged adults, predict cardiac failure in patients after acute coronary syndromes, help establish the diagnosis of heart failure with preserved ejection fraction in patients presenting with effort intolerance, and aid in the prognosis of both systolic and nonsystolic heart failure for the outcomes of hospitalization and death. This article presents case discussions of these applications to highlight the importance of galectin-3 measurement across the spectrum of patients at risk for cardiorenal disease.
Key words:  Galectin-3      Heart failure      Chronic kidney disease      Biomarker      Medical management      Hospitalization      Mortality     
Published:  30 September 2014     

Cite this article: 

Peter McCullough, Rudolph A. de Boer, Frank Edelmann, Connie M. Lewis, Alan S. Maisel. Utilization of Galectin-3 in Case Management Across the Spectrum of Heart Failure. Reviews in Cardiovascular Medicine, 2014, 15(3): 197-207.

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