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Reviews in Cardiovascular Medicine  2015, Vol. 16 Issue (2): 105-113     DOI: 10.3909/ricm0742
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Management of Patients With Stable Angina and Type 2 Diabetes
Prakash C. Deedwania
University of California, San Francisco, Fresno, CA
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Abstract:
Type 2 diabetes (T2D) is a well-established risk factor for patients with coronary artery disease (CAD). Patients with CAD and comorbid T2D also have a higher risk of cardiovascular complications, such as silent ischemia and stable angina. In treating the symptoms of stable angina in patients with CAD and comorbid T2D, it is vital to utilize therapies that reduce symptoms and improve outcomes. At the same time, there is significant concern about the preservation of glycometabolic parameters, such as glycosylated hemoglobin (HbA1c), particularly because some antianginal therapies, such as β-blockers and calcium channel blockers-although effective at improving the symptoms of stable angina and reducing ischemia-may also worsen glycemic control by increasing HbA1c levels. Available trial data on the efficacy of antianginal agents in patients with stable angina and comorbid T2D are limited. Therefore, in patients with stable angina and T2D, a tailored approach to treatment of stable angina by selecting therapies with a neutral or positive glycometabolic profile may improve outcomes and increase treatment compliance. Additionally, patients with a dual diagnosis may benefit from therapies that have beneficial effects on both stable angina and T2D, thereby reducing polypharmacy. Prospective studies in patients with stable angina and T2D are needed to guide therapy decisions.
Key words:  Coronary artery disease      Ranolazine      Stable angina      Type 2 diabetes     
Published:  30 June 2015     

Cite this article: 

Prakash C. Deedwania. Management of Patients With Stable Angina and Type 2 Diabetes. Reviews in Cardiovascular Medicine, 2015, 16(2): 105-113.

URL: 

https://rcm.imrpress.com/EN/10.3909/ricm0742     OR     https://rcm.imrpress.com/EN/Y2015/V16/I2/105

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