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Reviews in Cardiovascular Medicine  2015, Vol. 16 Issue (4): 225-234     DOI: 10.3909/ricm0779
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Cardiotoxicity of Anticancer Therapies
Raghunandan Muppidi1, Laura Spranklin2, William Scialla2, Nauman Islam1, Ronald Freudenberger1, Robert Malacoff1
1 Department of Cardiology, Lehigh Valley Health Network, Allentown, PA
2 Department of Hematology-Oncology, Lehigh Valley Health Network, Allentown, PA
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Cardiovascular diseases and cancer continue to remain major causes of mortality and morbidity. However, overall cancer death rates have declined 20% from their peak in 1991. These declines reflect changing patterns in smoking, prevention, earlier diagnosis, and better treatment options in chemotherapy. It is recognized that this improved survival with better cancer therapies has put patients at risk for cardiovascular disease later in life; this may be secondary to risk factors for developing cardiovascular disease or the effect of anticancer therapies. Earlier detection, identifying patients at risk of developing cardiotoxicity, and early institution of treatment are paramount to decreasing morbidity associated with cardiotoxicity. Adverse cardiac effects have been observed and reported with a wide variety of chemotherapeutic agents. Herein we review cardiac effects of some of the common agents used in oncology.
Key words:  Cardiotoxicity      Anticancer therapy      Coronary artery disease      Cardiomyopathy     
Published:  30 December 2015     

Cite this article: 

Raghunandan Muppidi, Laura Spranklin, William Scialla, Nauman Islam, Ronald Freudenberger, Robert Malacoff. Cardiotoxicity of Anticancer Therapies. Reviews in Cardiovascular Medicine, 2015, 16(4): 225-234.

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