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Reviews in Cardiovascular Medicine  2018, Vol. 19 Issue (S1): 20-24     DOI: 10.3909/ricm19S1S0003
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Can We Cure Atherosclerosis?
Jennifer G. Robinson1, Michael H. Davidson2
1 Departments of Epidemiology & Medicine, University of Iowa College of Public Health and Carver College of Medicine, Iowa City, IA
2 Department of Cardiology, University of Chicago Medicine, Chicago, IL
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Cardiovascular disease mortality rates have begun to rise in the United States. Based on the large body of supportive evidence, we propose a proof-of-concept, first-in-human trial to cure atherosclerosis: CURing Early ATHEROsclerosis (CURE ATHERO). This trial is based on a model of intensive induction therapy for extensive, if not complete, plaque regression, followed by intermittent maintenance therapy. An extensive body of evidence has demonstrated the causal role of apolipoprotein B lipoproteins in atherosclerosis progression and data suggest intensive low-density lipoprotein cholesterol (LDL-C) lowering may have a substantial impact on earlier stages of atherosclerosis. Compared with lifetime treatment to prevent atherosclerosis progression, this induction–intermittent treatment model will minimize costs and maximize adherence and safety.
Key words:  Atherosclerosis      Regression      Primary prevention      Familial hypercholesterolemia      Apolipoprotein B lipoproteins      PCSK9 monoclonal antibodies      Statins     
Published:  20 January 2018     

Cite this article: 

Jennifer G. Robinson, Karol E. Watson. Can We Cure Atherosclerosis?. Reviews in Cardiovascular Medicine, 2018, 19(S1): 20-24.

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