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Reviews in Cardiovascular Medicine  2020, Vol. 21 Issue (3): 321-338     DOI: 10.31083/j.rcm.2020.03.102
Special Issue: Cardiac fibrosis
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Cardiac sarcoidosis: diagnosis and management
Eleftherios Markatis1, *(), Andreas Afthinos1, Emmanouil Antonakis1, Ilias C Papanikolaou1, *()
1Pulmonary Department, Corfu General Hospital, Corfu 49100, Greece
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Abstract:

Sarcoidosis is a chronic inflammatory disease of unknown etiology characterized by multi-organ involvement. End-organ disease consists of granulomatous inflammation, which if left untreated or not resolved spontaneously, leads to permanent fibrosis and end-organ dysfunction. Cardiac involvement and fibrosis in sarcoidosis occur in 5-10% of cases and is becoming increasingly diagnosed. This is due to increased clinical awareness among clinicians and new diagnostic modalities, since magnetic resonance imaging and positron-emission tomography are emerging as “gold standard” tools replacing endomyocardial biopsy. Despite this progress, isolated cardiac sarcoidosis is difficult to differentiate from other causes of arrhythmogenic cardiomyopathy. Cardiac fibrosis leads to congestive heart failure, arrhythmias and sudden cardiac death. Immunosuppressives (mostly corticosteroids) are used for the treatment of cardiac sarcoidosis. Implantable devices like a cardioverter-defibrillator may be warranted in order to prevent sudden cardiac death. In this article current trends in the pathophysiology, diagnosis and management of cardiac sarcoidosis will be reviewed focusing on published research and latest guidelines. Lastly, a management algorithm is proposed.

Key words:  Sarcoidosis      cardiac sarcoidosis      interstitial lung disease      fibrosis     
Submitted:  22 May 2020      Revised:  16 August 2020      Accepted:  18 August 2020      Published:  30 September 2020     
*Corresponding Author(s):  Eleftherios Markatis Email: lefte_mark83@yahoo.gr; Ilias C Papanikolaou Email: icpapanikolaou@hotmail.com   

Cite this article: 

Eleftherios Markatis, Andreas Afthinos, Emmanouil Antonakis, Ilias C Papanikolaou. Cardiac sarcoidosis: diagnosis and management. Reviews in Cardiovascular Medicine, 2020, 21(3): 321-338.

URL: 

https://rcm.imrpress.com/EN/10.31083/j.rcm.2020.03.102     OR     https://rcm.imrpress.com/EN/Y2020/V21/I3/321

Fig. 1.   A well-formed non-necrotizing granuloma in the heart (Hematoxylin Eosin x400).

Fig. 2.   Cardiac magnetic resonance images in a 54-year-old male with cardiac sarcoidosis, showing late gadolinium enhancement in the posterior-lateral left ventricle wall sub-epicardially (B, yellow arrows).

Table 1.  Japanese cardiac sarcoidosis and Heart Rhythm Society guidelines (Birnie et al., 2014; Terasaki et al., 2019).
2016 JCS Guideline on Diagnosis and Treatment of Cardiac Sarcoidosis 2014 HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis
• Histological diagnosis • Histological diagnosis
• Clinical diagnosis group when
A. Epithelioid granulomas are found in organs other than the heart, and two or more major criteria or one major and two or more minor criteria • Clinical diagnosis of cardiac sarcoidosis (probable CS) meaning histological diagnosis of extra cardiac sarcoidosis, exclusion of other diagnoses and one or more of
Major criteria
1. High-grade atrioventricular block (including complete atrioventricular block) or fatal ventricular arrhythmia (e.g., sustained ventricular tachycardia, and ventricular fibrillation) 1. cardiomyopathy and/or heart block unexplained reduced left ventricular ejection fraction (LVEF) of less than 40%
2. Basal thinning of the ventricular septum or abnormal ventricular wall anatomy (ventricular aneurysm, thinning of the middle or upper ventricular septum, regional ventricular wall thickening) 2. unexplained sustained (spontaneous or induced) ventricular tachycardia
3. Left ventricular contractile dysfunction (left ventricular ejection fraction less than 50%) or focal ventricular wall asynergy
4. 67Ga citrate scintigraphy or FDG PET reveals abnormally high tracer accumulation in the heart 3. Mobitz type II second-degree AV block or third-degree AV block
5. Gadolinium-enhanced MRI reveals delayed contrast enhancement of the myocardium
Minor criteria
1. Abnormal ECG findings: Ventricular arrhythmias (nonsustained ventricular tachycardia, multifocal or frequent premature ventricular contractions), bundle branch block, axis deviation, or abnormal Q waves 4. patchy uptake of cardiac FDG-PET in a pattern consistent with cardiac sarcoidosis
2. Perfusion defects on myocardial perfusion scintigraphy (SPECT) 5. late gadolinium enhancement on CMRI in a pattern consistent with cardiac sarcoidosis
3. Endomyocardial biopsy: Monocyte infiltration and moderate or severe myocardial interstitial fibrosis
4. When the patient shows clinical findings strongly suggestive of pulmonary or ophthalmic sarcoidosis; at least 2 of the five characteristic laboratory findings of sarcoidosis and clinical findings strongly suggest cardiac involvement 6. positive gallium uptake in a pattern consistent with cardiac sarcoidosis
Table 2.  Probable cardiac sarcoidosis according to World Association of Sarcoidosis and Other Granulomatous diseases (WASOG) criteria (Crouser et al., 2020; Judson et al., 2014).
2014 The WASOG Sarcoidosis Organ Assessment Instrument 2020 Diagnosis and Detection of SarcoidosisAn Official American Thoracic Society Clinical Practice Guideline
Probable criteria Probable criteria
1. Treatment responsive Cardiomyopathy or atrioventricular nodal block 1. Treatment-responsive CM or AVNB
2. Reduced LVEF in the absence of other clinical risk factors 2. Reduced LVEF with no risk factors (echo and MRI)
3. Spontaneous or inducible sustained VT with no other risk factor 3. Spontaneous/inducible VT with no risk factors
4. Mobitz type II or 3rd degree heart block 4. New-onset, third-degree AV block in young or middle-aged adults
5. Patchy uptake on dedicated cardiac PET 5. Increased inflammatory activity in heart (MRI, PET, and gallium)
6. Delayed enhancement on CMR
7. Positive gallium uptake
8. Defect on perfusion scintigraphy or SPECT scan
9. T2 prolongation on CMR
(FDG) PET = (Fluorodeoxyglucose) positron emission tomography; MRI = magnetic resonance imaging; ECG = electrocardiogram; SPECT = Single-photon emission computed tomography; LVEF = left ventricular ejection fraction; VT = ventricular tachycardia; CM = cardiomyopathy; AVNB = atrioventricular node block; AV = atrioventricular
Fig. 3.  FDG-PET of a 63-year-old female on methotrexate for cardiac sarcoidosis before (a) and during (b) therapy with methotrexate for 2 years, exhibiting a significant decrease in FDG uptake in the heart suggesting adequate response to therapy. The scan continues to show FDG uptake in mediastinal lymph nodes (Bremer et al., 2018)

Table 3.  Studies on cardiac sarcoidosis treatment.
Authors Number of patients Year of study High dose Immunosuppresion Tapering Low dose Immunosuppresion
Yazaki et al., 2001 95 2001 Prednisone 30-60 mg/d Variable Prednisone 5 to 15 mg/d
Chapelon-Abric et al., 2004 41 2004 IV prednisolone 15mg/kg × 3d Variable Not reported
Chiu et al., 2005 43 2005 Prednisone 60 mg 2 months Prednisone 10 mg/ d
Nagai et al., 2014 17, 67 2014, 2015 Prednisone 30 to 40 mg/d Variable Prednisolone 5 to 15 mg/d
Ballul et al., 2019 36 2016 Prednisone 60 mg/d Not reported Not reported
Fussner et al., 2018 91 2018 Prednisone 40-60 mg/d Variable Variable
Fig. 4.  Suggested management algorithm for patients with probable cardiac sarcoidosis. ATS, American thoracic society criteria, biopsy of extra cardiac site; ECG, electrocardiogram; CMR, cardiac magnetic resonance, PET, positron emission tomography; VA, ventricular arrythmias; LVEF, left ventricle ejection fraction; EPS, electrophysiologic study; ICD, implantable cardioverter defibrillator.

[1] Abe, C., Iwai, K., Mikami, R. and Hosoda, Y. (1984) Frequent isolation of propionibacterium acnes from sarcoidosis lymph nodes. Zentralblatt FÜR Bakteriologie, Mikrobiologie Und Hygiene. 1. Abt. Originale. a, Medizinische Mikrobiologie, Infektionskrankheiten Und Parasitologie 256, 541-547.
[2] Abe, S., Yamaguchi, E., Makimura, S., Okazaki, N., Kunikane, H. and Kawakami, Y. (1987) Association of HLA-DR with sarcoidosis. Chest 92, 488-490.
[3] Agarwal, A., Sulemanjee, N. Z., Cheema, O., Downey, F. X. and Tajik, A. J. (2014) Cardiac sarcoid: A chameleon masquerading as hypertrophic cardiomyopathy and dilated cardiomyopathy in the same patient. Echocardiography 31, E138-E141.
[4] Agoston-Coldea, L., Kouaho, S., and Sacre, K. (2016) High mass (> 18 g) of late gadolinium enhancement on CMR imaging is associated with major cardiac events on long-term outcome in patients with biopsy proven extra-cardiac sarcoidosis. International Journal of Cardiology 222, 950-956.
[5] Aizer, A., Stern, E. H., Gomes, J. A., Teirstein, A. S., Eckart, R. E. and Mehta, D. (2005) Usefulness of programmed ventricular stimulation in predicting future arrhythmic events in patients with cardiac sarcoidosis. American Journal of Cardiology 96, 276-282.
[6] Arkema, E. V. and Cozier, Y. C. (2018) Epidemiology of sarcoidosis: current findings and future directions. Therapeutic Advances in Chronic Disease 9, 227-240.
[7] Aryal, S. and Nathan, S. D. (2019) Contemporary optimized practice in the management of pulmonary sarcoidosis. Therapeutic Advances in Respiratory Disease 13, 1753466619868935.
[8] Asakawa, N., Uchida, K., Sakakibara, M., Omote, K., Noguchi, K., Tokuda, Y., Kamiya, K., Hatanaka, K. C., Matsuno, Y., Yamada, S., Asakawa, K., Fukasawa, Y., Nagai, T., Anzai, T., Ikeda, Y., Ishibashi-Ueda, H., Hirota, M., Orii, M., Akasaka, T., Uto, K., Shingu, Y., Matsui, Y., Morimoto, S., Tsutsui, H. and Eishi, Y. (2017) Immunohistochemical identification of propionibacterium acnes in granuloma and inflammatory cells of myocardial tissues obtained from cardiac sarcoidosis patients. Plos One 12, e0179980.
[9] Ballul, T., Borie, R., Crestani, B., Daugas, E., Descamps, V., Dieude, P., Dossier, A., Extramiana, F., van Gysel, D., Papo, T, and Sacre, K. (2019) Treatment of cardiac sarcoidosis: a comparative study of steroids and steroids plus immunosuppressive drugs. International Journal of Cardiology 276, 208-211.
[10] Banba, K., Kusano, K. F., Nakamura, K., Morita, H., Ogawa, A., Ohtsuka, F., Ogo, K. O., Nishii, N., Watanabe, A., Nagase, S., Sakuragi, S. and Ohe, T. (2007) Relationship between arrhythmogenesis and disease activity in cardiac sarcoidosis. Heart Rhythm journal 4, 1292-1299.
[11] Bargagli, E. and Prasse, A. (2018) Sarcoidosis: a review for the internist. Internal and Emergency Medicine 16.
[12] Baughman, R. P., Drent, M., Kavuru, M., Judson, M. A., Costabel, U., du Bois, R., Albera, C., Brutsche, M., Davis, G., Donohue, J. F., Mueller-Quernheim, J., Schlenker-Herceg, R., Flavin, S., Lo, K. H., Oemar, B. and Barnathan, E. S. (2006) Sarcoidosis I. infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement. American Journal of Respiratory and Critical Care Medicine 174, 795-802.
[13] Baughman, R. P., Lower, E. E. and du Bois, R. M. (2003) Sarcoidosis. The Lancet 361, 1111-1118.
[14] Baughman, R., Teirstein, A., Judson, M., Rossman, M., Yeager, H., Bresnitz, E., DePalo, L., Hunninghake, G., Iannuzzi, M., Johns, C., McLennan, G., Moller, D., Newman, L., Rabin, D., Rose, C., Rybicki, B., Weinberger, S., Terrin, M., Knatterud, G., Cherniak, R. and Group, A. E. (2001) Clinical characteristics of patients in a case control study of sarcoidosis. American Journal of Respiratory and Critical Care Medicine 164, 1885-1889.
[15] Beegle, S. H., Barba, K., Gobunsuy, R. and Judson, M. A. (2013) Current and emerging pharmacological treatments for sarcoidosis: a review. Drug Design Development and Therapy journal 7, 525-538.
[16] Berlin, M., Fogdell-Hahn, A., Olerup, O., Eklund, A. and Grunewald, J. (1997) HLA-DR predicts the prognosis in scandinavian patients with pulmonary sarcoidosis. American Journal of Respiratory and Critical Care Medicine 156, 1601-1605.
[17] Bernstein, M. (1929) Boeck’s sarcoid. Archives of Internal Medicine 44, 721.
[18] Betensky, B. P., Tschabrunn, C. M., Zado, E. S., Goldberg, L. R., Marchlinski, F. E. and Garcia, F. C. (2012) Long-term follow-up of patients with cardiac sarcoidosis and implantable cardioverter-defibrillators. Heart Rhythm journal 9, 884-891.
[19] Birnbaum, A. D., Oh, F. S., Ckakrabarti, A., Tessler, H. H., and Goldstein, D. A. (2011) Clinical features and diagnostic evaluation of biopsy-proven ocular sarcoidosis. Archives of Ophthalmology 129, 409-413.
[20] Birnie, D. H., Nery, P. B., Ha, A. C. and Beanlands, R. S. B. (2016) Cardiac sarcoidosis. Journal of the American College of Cardiology 68, 411-421.
[21] Birnie, D. H., Sauer, W. H., Bogun, F., Cooper, J. M., Culver, D. A., Duvernoy, C. S., Judson, M. A., Kron, J., Mehta, D., Cosedis Nielsen, J., Patel, A. R., Ohe, T., Raatikainen, P. and Soejima, K. (2014) HRS expert consensus statement on the diagnosis and management of arrhythmias associated with cardiac sarcoidosis. Heart Rhythm 11, 1304-1323.
[22] Blankstein, R., Osborne, M., Naya, M., Waller, A., Kim, C. K., Murthy, V. L., Kazemian, P., Kwong, R. Y., Tokuda, M., Skali, H., Padera, R., Hainer, J., Stevenson, W. G., Dorbala, S., and Di Carli, M. F. (2014) Cardiac positron emission tomography enhances prognostic assessments of patients with suspected cardiac sarcoidosis. Journal of the American College of Cardiology 63, 329-336.
[23] Bremer, W., Sweiss, N. J.and Lu, Y. (2018) Serial FDG-PET/CT imaging in the management of cardiac sarcoidosis. Clinical Nuclear Medicine 43, e50-e52.
[24] Brennan, N. J., Crean, P., Long, J. P. and Fitzgerald, M. X. (1984) High prevalence of familial sarcoidosis in an Irish population. Thorax 39, 14-18.
[25] Brewerton, D. A., Cockburn, C., James, D. C., James, D. G. and Neville, E. (1977) HLA antigens in sarcoidosis. Clinical and Experimental Immunology 27, 227-229.
[26] Brito-Zerón, P., Sellarés, J., Bosch, X., Hernández, F., Kostov, B., Sisó-Almirall, A., Lopez Casany, C., Santos, J. M., Paradela, M., Sánchez, M., Ramírez, J., Xaubet, A., Agustí, C. and Ramos-Casals, M. (2016) Epidemiologic patterns of disease expression in sarcoidosis: age, gender and ethnicity-related differences. Clinical and Experimental Rheumatology 34, 380-388.
[27] Burstow, D. J., Tajik, A. J., Bailey, K. R., DeRemee, R. A. and Taliercio, C. P. (1989) Two-dimensional echocardiographic findings in systemic sarcoidosis. The American Journal of Cardiology 63, 478-482.
[28] Byg, K. E., Milman, N., and Hansen, S. (2003) Sarcoidosis in Denmark 1980-1994: a registry-based incidence study comprising 5536 patients. Sarcoidosis Vasculitis and Diffuse Lung Diseases journal 20, 46-52.
[29] Cameli, P., Barbagli, E. and Rottoli, P. (2016) Exhaled nitric oxide is not increased in pulmonary sarcoidosis. Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG 33, 39-40.
[30] Cameli, P., Gonnelli, S., Bargagli, E., d’Alessandro, M., Bergantini, L., Favetta, V., Tomai Pitinca, M., Lisi, E., Refini, R., Pieroni, M., Sestini, P. and Caffarelli, C. (2020) The role of urinary calcium and chitotriosidase in a cohort of chronic sarcoidosis patients. Respiration 99, 207-212.
[31] Chang, T. I., Chi, N. H., Chou, N. K., Tsao, C. I., Yu, H. Y., Chen, Y. S., and Wang, S. S. (2012) Isolated cardiac sarcoidosis in heart transplantation. Transplantation Proceedings 44, 903-906.
[32] Chapelon-Abric, C., de Zuttere, D., Duhaut, P., Veyssier, P., Wechsler, B., Huong, D. L., de Gennes, C., Papo, T., Bletry, O., Godeau, P. and Piette, J. C. (2004) Cardiac sarcoidosis-a retrospective study of 41 cases. Medicine 83, 315-334.
[33] Chareonthaitawee, P., Beanlands, R. S., Chen, W., Dorbala, S., Miller, E. J., Murthy, V. L., Birnie, D. H., Chen, E. S., Cooper, L. T., Tung, R. H., White, E. S., Borges-Neto, S., Di Carli, M. F., Gropler, R. J., Ruddy, T. D., Schindler, T. H., and Blankstein, R. (2017) Joint SNMMI-ASNC expert consensus document on the role of 18F-FDG PET/ CT in cardiac sarcoid detection and therapy monitoring. Journal of Nuclear Cardiology 24, 1741-1758.
[34] Chen, E. S. and Moller, D. R. (2008) Etiology of sarcoidosis. Clinics in Chest Medicine 29, 365-377.
[35] Cheong, B. Y., Muthupillai, R., Nemeth, M., Lambert, B., Dees, D., Huber, S., Castriotta, R., and Flamm S. D. (2009) The utility of delayed enhancement magnetic resonance imaging for identifying nonischemic myocardial fibrosis in asymptomatic patients with biopsy-proven systemic sarcoidosis. Sarcoidosis Vasculitis and Diffuse Lung Diseases Journal 26, 39-46.
[36] Chiu, C. Z., Nakatani, S., Zhang, G., Tachibana, T., Ohmori, F., Yamagishi, M., Kitakaze, M., Tomoike, H. and Miyatake, K. (2005) Prevention of left ventricular remodeling by long-term corticosteroid therapy in patients with cardiac sarcoidosis. American Journal of Cardiology 95, 143-146.
[37] Coleman, G. C., Shaw, P. W., Balfour, P. C. Jr., Gonzalez, J. A., Kramer, C. M., Patel, A. R., and Salerno, M. (2017) Prognostic value of myocardial scarring on CMR in patients with cardiac sarcoidosis. JACC Cardiovascular Imaging 10, 411-420.
[38] Costabel, U. (2001) Sarcoidosis: clinical update. European Respiratory Journal 32, 56s-68s.
[39] Hunninghake, G. W., Costabel, U., Ando, M., Baughman, R., Cordier, J. F., du Bois, R., Eklund, A., Kitaichi, M., Lynch, J., Rizzato, G., Rose, C., Selroos, O., Semenzato, G., and Sharma, O. P. (1999) ATS/ERS/WASOG statement on sarcoidosis. American Thoracic Society/European Respiratory Society/World Association of Sarcoidosis and other Granulomatous Disorders. Sarcoidosis Vasculitis and Diffuse Lung Diseases: Official Journal of WASOG 16, 149-173.
[40] Cox, C. E., Donohue, J. F., Brown, C. D., Kataria, Y. P. and Judson, M. A. (2004) Health-related quality of life of persons with sarcoidosis. Chest Journal 125, 997-1004.
[41] Cozier, Y. C. (2016) Assessing the worldwide epidemiology of sarcoidosis: challenges and future directions. European Respiratory Journal 48, 1545-1548.
[42] Cozier, Y. C., Berman, J. S., Palmer, J. R., Boggs, D. A., Serlin, D. M. and Rosenberg, L. (2011) Sarcoidosis in Black Women in the United States. Chest 139, 144-150.
[43] Cozier, Y. C., Coogan, P. F., Govender, P., Berman, J. S., Palmer, J. R. and Rosenberg, L. (2015) Obesity and weight gain in relation to incidence of sarcoidosis in US black women. Chest 147, 1086-1093.
[44] Cozier, Y. C., Ruiz-Narvaez, E. A., McKinnon, C. J., Berman, J. S., Rosenberg, L. and Palmer, J. R. (2012) Fine-mapping in African-American women confirms the importance of the 10p12 locus to sarcoidosis. Genes & Immunity 13, 573-578.
[45] Cozier, Y., Ruiz-Narvaez, E., McKinnon, C., Berman, J., Rosenberg, L. and Palmer, J. (2013) Replication of genetic loci for sarcoidosis in US black women: data from the Black Women’s Health Study. Human Genetics 132, 803-810.
[46] Crawford, T., Mueller, G., Sarsam, S., Prasitdumrong, H., Chaiyen, N., Xioukui, G., Schuller, J., Kron, J., Nour, K. A., Cheng, A., Ji, S. Y., Feinstein, S., Gupta, S., Ilg, K., Sinno, M., Abu-Hashish, S., Al-Mallah, M., Sauer, W. H., Ellenbogen, K., Morady, F., and Bogun, F. (2014) Magnetic resonance imaging for identifying patients with cardiac sarcoidosis and preserved or mildly reduced left ventricular function at risk of ventricular arrhythmias. Circulation Arrhythmia and Electrophysiology Journal 7, 1109-1115.
[47] Crouser, E. D., Maier, L. A., Wilson, K. C., Bonham, C. A., Morgenthau, A. S., Patterson, K. C., Abston, E., Bernstein, R. C., Blankstein, R., Chen, E. S., Culver, D. A., Drake, W., Drent, M., Gerke, A. K., Ghobrial, M., Govender, P., Hamzeh, N., James, W. E., Judson, M. A., Kellermeyer, L., Knight, S., Koth, L. L., Poletti, V., Raman, S. V., Tukey, M. H., Westney, G. E., and Baughman, R. P. (2020) Diagnosis and detection of sarcoidosis: an official American Thoracic Society clinical practice guideline. American Journal of Respiratory and Critical Care Medicine 201, e26‐e51.
[48] Crouser, E. D., Ono, C., Tran, T., He, T., and Raman, S. V. (2014) Improved detection of cardiac sarcoidosis using magnetic resonance with myocardial T2 mapping. American Journal of Respiratory and Critical Care Medicine 189, 109-112.
[49] Crowley, L. E., Herbert, R., Moline, J. M., Wallenstein, S., Shukla, G., Schechter, C., Skloot, G. S., Udasin, I., Luft, B. J., Harrison, D., Shapiro, M., Wong, K., Sacks, H. S., Landrigan, P. J. and Teirstein, A. S. (2011) “Sarcoid like” granulomatous pulmonary disease in World Trade Center disaster responders. American Journal of Industrial Medicine 54, 175-184.
[50] Judson, M. A., Boan, A. D., Lackland, D. T. (2012) The clinical course of sarcoidosis: presentation, diagnosis, and treatment in a large white and black cohort in the United States. Sarcoidosis Vasculitis and Diffuse Lung Diseases Journal 29, 119-127.
[51] Cummings, K. W., Bhalla, S., Javidan-Nejad, C., Bierhals, A. J., Gutierrez, F. R., and Woodard, P. K. (2009) A pattern-based approach to assessment of delayed enhancement in nonischemic cardiomyopathy at MR imaging. Radiographics 29, 89-103.
[52] d’Alessandro, M., Carleo, A., Cameli, P., Bergantini, L., Perrone, A., Vietri, L., Lanzarone, N., Vagaggini, C., Sestini, P. and Bargagli, E. (2020) BAL biomarkers’ panel for differential diagnosis of interstitial lung diseases. Clinical and Experimental Medicine 20, 207-216.
[53] d’Alessandro, M., Bergantini, L., Perrone, A., Cameli, P., Cameli, M., Prasse, A., Plataroti, D., Sestini, P. and Bargagli, E. (2020) Serial investigation of angiotensin-converting enzyme in sarcoidosis patients treated with angiotensin-converting enzyme inhibitor. European Journal of Internal Medicine 78, 58-62.
[54] Darlington, P., Gabrielsen, A., Sörensson, P., Cederlund, K., Eklund, A. and Grunewald, J. (2014) Cardiac involvement in Caucasian patients with pulmonary sarcoidosis. Respiratory Research 15, 15.
[55] Darlington, P., Haugom-Olsen, H., von Sivers, K., Wahlström, J., Runold, M., Svjatoha, V., Porwit, A., Eklund, A. and Grunewald, J. (2012) T-cell phenotypes in bronchoalveolar lavage fluid, blood and lymph nodes in pulmonary sarcoidosis - indication for an airborne antigen as the triggering factor in sarcoidosis. Journal of Internal Medicine 272, 465-471.
[56] Dechering, D. G., Kochhäuser, S., Wasmer, K., Zellerhoff, S., Pott, C., Köbe, J., Spieker, T., Piers, S. R., Bittner, A., Mönnig, G., Breithardt, G., Wichter, T., Zeppenfeld, K., and Eckardt, L. (2013) Electrophysiological characteristics of ventricular tachyarrhythmias in cardiac sarcoidosis versus arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm journal 10, 158-164.
[57] Demeter, S. L. (1988) Myocardial sarcoidosis unresponsive to steroids. Treatment with cyclophosphamide. Chest journal 94, 202-203.
[58] Demirkok, S. S., Basaranoglu, M., Çoker, E. and Karayel, T. (2007) Seasonality of the onset of symptoms, Tuberculin test anergy and Kveim positive reaction in a large cohort of patients with sarcoidosis. Respirology 12, 591-593.
[59] Deubelbeiss, U., Gemperli, A., Schindler, C., Baty, F. and Brutsche, M. H. (2010) Prevalence of sarcoidosis in Switzerland is associated with environmental factors. European Respiratory Journal 35, 1088-1097.
[60] Hiraga, H., Yuwai, K., and Hiroe, M. (2007) Diagnostic standard and guidelines for sarcoidosis. Jpn J Sarcoidosis Granulomatous Disord 27, 89-102.
[61] Doughan, A. R. and Williams, B. R. (2006) Cardiac sarcoidosis. Heart journal 92, 282‐288.
[62] Dubrey, S. W. and Falk, R. H. (2010) Diagnosis and management of cardiac sarcoidosis. Progress in Cardiovascular Diseases 52, 336-346.
[63] Ekstrom, K., Lehtonen, J., Hanninen, H., Kandolin, R., Kivisto, S. and Kupari, M. (2016) Magnetic resonance imaging as a predictor of survival free of life-threatening arrhythmias and transplantation in cardiac sarcoidosis. Journal of the American Heart Association 5, e003040.
[64] Ekström, K., Lehtonen, J., Hänninen, H., Kandolin, R., Kivistö, S., and Kupari, M. (2016) Magnetic resonance imaging as a predictor of survival free of life-threatening arrhythmias and transplantation in cardiac sarcoidosis. Journal of the American Heart Association 5, e003040.
[65] Erdal, B. S., Clymer, B. D., Yildiz, V. O., Julian, M. W. and Crouser, E. D. (2012) Unexpectedly high prevalence of sarcoidosis in a representative U.S. Metropolitan population. Respiratory Medicine 106, 893-899.
[66] Foreman, M. G., Mannino, D. M., Kamugisha, L. and Westney, G. E. (2006) Hospitalization for patients with sarcoidosis: 1979-2000. Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG 23, 124-129.
[67] Freeman, A. M., Curran-Everett, D., Weinberger, H. D., Fenster, B. E., Buckner, J. K., Gottschall, E. B., Sauer, W. H., Maier, L. A. and Hamzeh, N. Y. (2013) Predictors of cardiac sarcoidosis using commonly available cardiac studies. American Journal of Cardiology 112, 280-285.
[68] From, A. M., Maleszewski, J. J. and Rihal, C. S. (2011) Current Status of Endomyocardial Biopsy. Mayo Clinic Proceedings 86, 1095-1102.
[69] Furushima, H., Chinushi, M., Sugiura, H., Kasai, H., Washizuka, T. and Aizawa, Y. (2004) Ventricular tachyarrhythmia associated with cardiac sarcoidosis: its mechanisms and outcome. Clinical Cardiology 27, 217-222.
[70] Fussner, L. A., Karlstedt, E., Hodge, D. O., Fine, N. M., Kalra, S., Carmona, E. M., Utz, J. P., Isaac, D. L. and Cooper, L. T. (2018) Management and outcomes of cardiac sarcoidosis: a 20-year experience in two tertiary care centers. European Journal of Heart Failure 20, 1713-1720.
[71] Gerke, A. K. (2014) Morbidity and mortality in sarcoidosis. Current Opinion in Pulmonary Medicine 20, 472-478.
[72] Giudicatti, L., Marangou, J., Nolan, D., Dembo, L., Baumwol, J., and Dwivedi, G. (2020) The utility of whole body 18F-FDG PET-CT in diagnosing isolated cardiac sarcoidosis: the western Australian cardiac sarcoid study. Heart Lung Circulation journal 29, e1-e6.
[73] Greulich, S., Deluigi, C. C., Gloekler, S., Wahl, A., Zürn, C., Kramer, U., Nothnagel, D., Bültel, H., Schumm, J., Grün, S., Ong, P., Wagner, A., Schneider, S., Nassenstein, K., Gawaz, M., Sechtem, U., Bruder, O. and Mahrholdt, H. (2013) CMR imaging predicts death and other adverse events in suspected cardiac sarcoidosis. JACC: Cardiovascular Imaging 6, 501-511.
[74] Gribbin, J., Hubbard, R. B., Le Jeune, I., Smith, C. J. P., West, J. and Tata, L. J. (2006) Incidence and mortality of idiopathic pulmonary fibrosis and sarcoidosis in the UK. Thorax 61, 980-985.
[75] Grubić, Z., Peros-Golubicić, T., Stingl, K., and Zunec, R. (2011) The investigation of HLA microsatellites influence in predisposition to sarcoidosis among Croatians. Sarcoidosis Vasculitis and Diffuse Lung Diseases journal 28, 18‐26.
[76] Grunewald, J., Eklund, A. and Olerup, O. (2004) Human leukocyte antigen class I Alleles and the disease course in sarcoidosis patients. American Journal of Respiratory and Critical Care Medicine 169, 696-702.
[77] Grutters, J. C. and van den Bosch, J. M. (2006) Corticosteroid treatment in sarcoidosis. European Respiratory Journal 28, 627-636.
[78] Gupta, D., Agarwal, R. and Aggarwal, A. N. (2013) Seasonality of sarcoidosis: the ’heat’ is on…. Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG 30, 241-243.
[79] Hamzeh, N. Y., Wamboldt, F. S. and Weinberger, H. D. (2012) Management of cardiac sarcoidosis in the United States: a Delphi study. Chest journal 141, 154-162.
[80] Hamzeh, N., Steckman, D. A., Sauer, W. H. and Judson, M. A. (2015) Pathophysiology and clinical management of cardiac sarcoidosis. Nature Reviews Cardiology 12, 278‐288.
[81] Hattori, T., Konno, S., Shijubo, N., Yamaguchi, T., Sugiyama, Y., Honma, S., Inase, N., Ito, Y. M. and Nishimura, M. (2018) Nationwide survey on the organ-specific prevalence and its interaction with sarcoidosis in Japan. Scientific Reports 8, 9440.
[82] Hedfors, E., and Lindstrom, F. (1983) HLA-B8/DR3 in sarcoidosis: correlation to acute onset disease with arthritis. Tissue Antigens 22, 200-203.
[83] Henke, C. E., Henke, G., Elveback, L. R., Beard, C. M., Ballard, D. J. and Kurland, L. T. (1986) The epidemiology of sarcoidosis in Rochester, Minnesota: a population-based study of incidence and survival. American Journal of Epidemiology 123, 840-845.
[84] Hillerdal, G., Nöu, E., Osterman, K. and Schmekel, B. (1984) Sarcoidosis: epidemiology and prognosis. A 15-year European study. The American Review of Respiratory Disease 130, 29-32.
[85] Hiraga, H., Yuwa, K., and Hiroe, M. (1993) Guideline for diagnosis of cardiac sarcoidosis: study report on diffuse pulmonary diseases. In Japanese: The Japanese ministry of health, labour and welfare, Tokyo, Japan, 23-24.
[86] Homma, J. Y., Abe, C., Chosa, H., Ueda, K., Saegusa, J., Nakayama, M., Homma, H., Washizaki, M. and Okano, H. (1978) Bacteriological investigation on biopsy specimens from patients with sarcoidosis. The Japanese Journal of Experimental Medicine 48, 251-255.
[87] Honda, Y., Nagai, T., Ikeda, Y., Sakakibara, M., Asakawa, N., Nagano, N., Nakai, M., Nishimura, K., Sugano, Y., Ohta‐Ogo, K., Asaumi, Y., Aiba, T., Kanzaki, H., Kusano, K., Noguchi, T., Yasuda, S., Tsutsui, H., Ishibashi‐Ueda, H. and Anzai, T. (2016) Myocardial immunocompetent cells and macrophage phenotypes as histopathological surrogates for diagnosis of cardiac sarcoidosis in japanese. Journal of the American Heart Association 5, e004019.
[88] Hoogendoorn, J. C., Sramko, M., Venlet, J., Siontis, Κ. C., Kumar, S., Singh, R., Nakajima. I., Piers, S. R., de Riva Silva, M., Glashan, C. A., Crawford, T., Tedrow, U. B., Stevenson, W. G., Bogun, F. and Zeppenfeld, K. (2020) Electroanatomical voltage mapping to distinguish right-sided cardiac sarcoidosis from arrhythmogenic right ventricular cardiomyopathy. JACC Clinical Electrophysiology journal 6, 696-707.
[89] Huang, H., Lu, Z., Jiang, C., Liu, J., Wang, Y. and Xu, Z. (2013) Imbalance between Th17 and Regulatory T-Cells in sarcoidosis. International Journal of Molecular Sciences 14, 21463-21473.
[90] Hulten, E., Agarwal, V., Cahill, M., Cole, G., Vita, T., Parrish, S., Bittencourt, M. S., Murthy, V. L., Kwong, R., Di Carli, M. F. and Blankstein, R. (2016) Presence of late gadolinium enhancement by cardiac magnetic resonance among patients with suspected cardiac sarcoidosis is associated with adverse cardiovascular prognosis: a systematic review and meta-analysis. Circulation Cardiovascular Imaging 9, e005001.
[91] Iannuzzi, M. (2007) Genetics of sarcoidosis. Seminars in Respiratory and Critical Care Medicine 28, 015-021.
[92] Iannuzzi, M. C., and Fontana, J. R. (2011) Sarcoidosis: clinical presentation, immunopathogenesis, and therapeutics. Journal of the American Medical Association 305, 391-399.
[93] Iannuzzi, M. C., Maliarik, M. J., Poisson, L. M. and Rybicki, B. A. (2003) Sarcoidosis susceptibility and resistance HLA-DQB1 Alleles in African Americans. American Journal of Respiratory and Critical Care Medicine 167, 1225-1231.
[94] Iannuzzi, M. C., Rybicki, B. A. and Teirstein, A. S. (2007) Sarcoidosis. New England Journal of Medicine 357, 2153-2165.
[95] Ichinose, A., Otani, H., Oikawa, M., Akase, K., Saito, H., Shimokawa, H., and Takahashi, S. (2008) MRI of cardiac sarcoidosis: basal and subepicardial localization of myocardial lesions and their effect on left ventricular function. American Journal of Roentgenology 191, 862-869.
[96] Ise, T., Hasegawa, T., Morita, Y., Yamada, N., Funada, A., Takahama, H., Amaki, M., Kanzaki, H., Okamura, H., Kamakura, S., Shimizu, W., Anzai, T., and Kitakaze, M. (2014) Extensive late gadolinium enhancement on cardiovascular magnetic resonance predicts adverse outcomes and lack of improvement in LV function after steroid therapy in cardiac sarcoidosis. Heart journal 100, 1165-1172.
[97] Ishige, I., Usui, Y., Takemura, T. and Eishi, Y. (1999) Quantitative PCR of mycobacterial and propionibacterial DNA in lymph nodes of Japanese patients with sarcoidosis. The Lancet 354, 120-123.
[98] Ishihara, M., Ohno, S., Ishida, T., Ando, H., Naruse, T., Nose, Y. and Inoko, H. (1994) Molecular genetic studies of HLA class II alleles in sarcoidosis. Tissue Antigens 43, 238-241.
[99] Ishimaru, S., Tsujino, I., Sakaue, S., Oyama, N., Takei, T., Tsukamoto, E., Tamaki, N., and Nishimura, M. (2005) Combination of 18F-fluoro-2-deoxyglucose positron emission tomography and magnetic resonance imaging in assessing cardiac sarcoidosis. Sarcoidosis Vasculitis and Diffuse Lung Diseases journal 22, 234-235.
[100] Ishimaru, S., Tsujino, I., Takei, T., Tsukamoto, E., Sakaue, S., Kamigaki, M., Ito, N., Ohira, H., Ikeda, D., Tamaki, N., and Nishimura, M. (2005) Focal uptake on 18F-fluoro-2-deoxyglucose positron emission tomography images indicates cardiac involvement of sarcoidosis. European Heart Journal 26, 1538-1543.
[101] Iwai, K., Sekiguti, M., Hosoda, Y., DeRemee, R. A., Tazelaar, H. D., Sharma, O. P., Maheshwari, A. and Noguchi, T. I. (1994) Racial difference in cardiac sarcoidosis incidence observed at autopsy. Sarcoidosis 11, 26-31.
[102] Iwai, K., Tachibana, T., Takemura, T., Matsui, Y., Kitalchi, M. and Kawabata, Y. (1993) Pathological studies on sarcoidosis autopsy. I. Epidemiological features of 320 cases in Japan. Pathology International 43, 372-376.
[103] Izumi, T. (1992) Symposium: population differences in clinical features and prognosis of sarcoidosis throughout the world. Sarcoidosis journal 9, S105-S118.
[104] Jain, R., Yadav, D., Puranik, N., Guleria, R. and Jin, J. (2020) Sarcoidosis: Causes, diagnosis, clinical features, and treatments. Journal of Clinical Medicine 9, 1081.
[105] James, D. G., and Hosoda, Y. (1994) Epidemiology. In: Sarcoidosis and Other Granulomatous Disorders. Edited by: James. New York, Marcel Dekker, 729-743.
[106] James, D. G., Neville, E., Siltzbach, L. E., Turiaf, J., Battesti, J. P., Sharma, O. P., Hosoda, Y., Mikami, R., Odaka, M., Villar, T. G., Djurič, B., Douglas, A. C., Middleton, W., Karlish, A., Blasi, A., Olivieri, D. and Press, P. (1976) A worldwide review of sarcoidosis. Annals of the New York Academy of Sciences 278, 321-334.
[107] Jefic, D., Joel, B., Good, E., Morady, F., Rosman, H., Knight, B. and Bogun, F. (2009) Role of radiofrequency catheter ablation of ventricular tachycardia in cardiac sarcoidosis: report from a multi-centre registry. Heart Rhythm journal 6, 189-195.
[108] Joyce, E., Department of Advanced Heart Disease; Brigham and Womens Hospital; Boston MA USA, Ninaber, M. K., Katsanos, S., Debonnaire, P., Department of Cardiology; Sint-Jan Hospital Bruges; Bruges Belgium, Kamperidis, V., Bax, J. J., Taube, C., Delgado, V. and Ajmone Marsan, N. (2015) Subclinical left ventricular dysfunction by echocardiographic speckle-tracking strain analysis relates to outcome in sarcoidosis. European Journal of Heart Failure 17, 51-62.
[109] Judson, M. A., Costabel, U., Drent, M., Wells, A., Maier, L., Koth, L., Shigemitsu, H., Culver, D. A., Gelfand, J., Valeyre, D., Sweiss, N., Crouser, E., Morgenthau, A. S., Lower, E. E., Azuma, A., Ishihara, M., Morimoto, S., Yamaguchi, T., Shijubo, N., Grutters, J. C., Rosenbach, M., Li, H. P., Rottoli, P., Inoue, Y., Prasse, A., Baughman, R. P., and Organ Assessment Instrument Investigators TW. (2014) The WASOG sarcoidosis organ assessment instrument: an update of a previous clinical tool. Sarcoidosis Vasculitis and Diffuse Lung Diseases journal 31, 19-27.
[110] Judson, M. A., Hirst, K., Iyengar, S. K., Rybicki, B. A., El Ghormli, L., Baughman, R. P., Donohue, J. F., Elston, R. C., Kavuru, M. S., Moller, D. R., Newman, L. S., Rabin, D. L., Rossman, M. D., Teirstein, A. S. and Iannuzzi, M. C. (2006) Comparison of sarcoidosis phenotypes among affected African-American siblings. Chest 130, 855-862.
[111] Kandolin, R., Lehtonen, J., Airaksinen, J., Vihinen, T., Miettinen, H., Kaikkonen, K., Haataja, P., Kerola, T. and Kupari, M. (2015) Usefulness of cardiac troponins as markers of early treatment response in cardiac sarcoidosis. The American Journal of Cardiology 116, 960-964.
[112] Kandolin, R., Lehtonen, J., Airaksinen, J., Vihinen, T., Miettinen, H., Ylitalo, K., Kaikkonen, K., Tuohinen, S., Haataja, P., Kerola, T., Kokkonen, J., Pelkonen, M., Pietilä-Effati, P., Utrianen, S., and Kupari, M. (2015) Cardiac sarcoidosis: epidemiology, characteristics, and outcome over 25 years in a nationwide study. Circulation 131, 624-632.
[113] Kandolin, R., Lehtonen, J., Graner, M., Schildt, J., Salmenkivi, K., Kivistö, S. M. and Kupari, M. (2011) Diagnosing isolated cardiac sarcoidosis. Journal of Internal Medicine 270, 461-468.
[114] Kim, J. S., Judson, M. A., Donnino, R., Gold, M., Cooper, L. T., Prystowsky, E. N. and Prystowsky, S. (2009) Cardiac sarcoidosis. American Heart Journal 157, 9-21.
[115] Korsten, P., Tampe, B., Konig, M. F. and Nikiphorou, E. (2018) Sarcoidosis and autoimmune diseases. Current Opinion in Pulmonary Medicine 24, 504-512.
[116] Kouranos, V., Tzelepis, G. E., Rapti, A., Mavrogeni, S., Aggeli, K., Douskou, M., Prasad, S., Koulouris, N., Sfikakis, P., Wells, A. and Gialafos, E. (2017) Complementary role of CMR to conventional screening in the diagnosis and prognosis of cardiac sarcoidosis. JACC: Cardiovascular Imaging 10, 1437-1447.
[117] Kouranos, V., Ward, S., Kokosi, M. A., Castillo, D., Chua, F., Judge, E. P., Thomas, S., Van Tonder, F., Devaraj, A., Nicholson, A. G., Maher, T. M., Renzoni, E. A., and Wells, A. U. (2020) Mixed ventilatory defects in pulmonary sarcoidosis: prevalence and clinical features. Chest Journal (in press)
[118] Kowalska, M., Niewiadomska, E. and Zejda, J. E. (2014) Epidemiology of sarcoidosis recorded in 2006-2010 in the Silesian voivodeship on the basis of routine medical reporting. Annals of Agricultural and Environmental Medicine: AAEM 21, 55-58.
[119] Kreider, M. E., Christie, J. D., Thompson, B., Newman, L., Rose, C., Barnard, J., Bresnitz, E., Judson, M. A., Lackland, D. T. and Rossman, M. D. (2005) Relationship of environmental exposures to the clinical phenotype of sarcoidosis. Chest 128, 207-215.
[120] Kron, J., Chicos, A., & Bogun, F. (2017) Treatment of cardiac sarcoidosis with steroids and steroid-sparing immunosuppressants: findings from the Cardiac Sarcoidosis Consortium. Heart Rhythm Society 38th Annual Scientific Sessions. Boston.
[121] Kron, J., Chicos, A., & Bogun, F. (2017) Treatment of cardiac sarcoidosis with steroids and steroid-sparing immunosuppressants: findings from the Cardiac Sarcoidosis Consortium. Heart Rhythm Society 38th Annual Scientific Sessions. Boston.
[122] Kron, J., Sauer, W., Mueller, G., Schuller, J., Bogun, F., Sarsam, S., Rosenfeld, L., Mitiku, T. Y., Cooper, J. M., Mehta, D., Greenspon, A. J., Ortman, M., Delurgio, D. B., Valadri, R., Narasimhan, C., Swapna, N., Singh, J. P., Danik, S., Markowitz, S. M., Almquist, A. K., Krahn, A. D., Wolfe, L. G., Feinstein, S., Ellenbogen, K. A., and Crawford, T. (2015) Outcomes of patients with definite and suspected isolated cardiac sarcoidosis treated with an implantable cardiac defibrillator. Journal of Interventional Cardiac Electrophysiology 43, 55-64.
[123] Kron, J., Sauer, W., Schuller, J., Bogun, F., Crawford, T., Sarsam, S., Rosenfeld, L., Mitiku, T. Y., Cooper, J. M., Mehta, D., Greenspon, A. J., Ortman, M., Delurgio, D. B., Valadri, R., Narasimhan, C., Swapna, N., Singh, J. P., Danik, S., Markowitz, S. M., Almquist, A. K., Krahn, A. D., Wolfe, L. G., Feinstein, S., Ellenbogen, K. (2013) Efficacy and safety of implantable cardiac defibrillators for treatment of ventricular arrhythmias in patients with cardiac sarcoidosis. Europace 15, 347-354.
[124] Kucera, G. P., Rybicki, B. A., Kirkey, K. L., Coon, S. W., Major, M. L., Maliarik, M. J. and Iannuzzi, M. C. (2003) Occupational Risk Factors for Sarcoidosis in African-American Siblings. Chest 123, 1527-1535.
[125] Kumita, S., Yoshinaga, K., Miyagawa, M., Momose, M., Kiso, K., Kasai, T., Naya, M., and Committee for diagnosis of cardiac sarcoidosis using 18F-FDG PET, Japanese Society of Nuclear Cardiology. (2019) Recommendations for 18F-fluorodeoxyglucose positron emission tomography imaging for diagnosis of cardiac sarcoidosis-2018 update: Japanese Society of Nuclear Cardiology recommendations. Journal of Nuclear Cardiology 26, 1414‐1433.
[126] Kusano, K. F. (2013) Effect of corticosteroid on arrhythmic events in patients with cardiac sarcoidosis. Journal of Cardiology 62, 326-327.
[127] Kusumoto, F. M., Schoenfeld, M. H., Barrett, C., Edgerton, J. R., Ellenbogen, K. A., Gold, M. R., Goldschlager, N. F., Hamilton, R. M., Joglar, J. A., Kim, R. J., Lee, R., Marine, J. E., McLeod, C. J., Oken, K. R., Patton, K. K., Pellegrini, C. N., Selzman, K. A., Thompson, A. and Varosy, P. D. (2019) 2018 ACC/AHA/HRS guideline on the evaluation and management of patients with bradycardia and cardiac conduction delay. Circulation 140, e382-e482.
[128] Lill, H., Kliiman, K., Altraja, A. and Department of Pulmonary Medicine; University of Tartu; Tartu Estonia (2016) Factors signifying gender differences in clinical presentation of sarcoidosis among Estonian population. The Clinical Respiratory Journal 10, 282-290.
[129] Lio, D., Candore, G., Romano, G. C., D’Anna, C., Gervasi, F., Di Lorenzo, G., Modica, M. A., Potestio, M. and Caruso, C. (1997) Modification of cytokine patterns in subjects bearing the HLA-B8DR3 phenotype: implications for autoimmunity. Cytokines, Cellular and Molecular Therapy 3, 217-224.
[130] Loddenkemper, R., Kloppenborg, A., Schoenfeld, N., Grosser, H., and Costabel, U. (1998) Clinical findings in 715 patients with newly detected pulmonary sarcoidosis-results of a cooperative study in former West Germany and Switzerland. WATL Study Group. Wissenschaftliche Arbeitsgemeinschaft für die Therapie von Lungenkrankheitan. Sarcoidosis Vasculitis and Diffuse Lung Diseases journal 15, 178-182.
[131] Macias, C., Nakamura, K., Tung, R., Boyle, N. G., Kalyanam, S. and Bradfield, J. S. (2014) Importance of delayed enhanced cardiac MRI In idiopathic RVOT-VT: differentiating mimics including early stage ARVC and cardiac sarcoidosis. Journal of Atrial Fibrillation 7, 1097.
[132] Maliarik, M., Chen, K., Major, M., Sheffer, R., Popovich, J., Rybicki, B. and Iannuzzi, M. (1998) Analysis of HLA-DPB1 polymorphisms in African-Americans with sarcoidosis. American Journal of Respiratory and Critical Care Medicine 158, 111-114.
[133] Mankad, P., Mitchell, B., Birnie, D. and Kron, J. (2019) Cardiac sarcoidosis. Current Cardiology Reports 21, 152.
[134] Mantini, N., Williams Jr., B., Stewart, J., Rubinsztain, L. and Kacharava, A. (2012) Cardiac sarcoid: A clinician’s review on how to approach the patient with cardiac sarcoid. Clinical Cardiology 35, 410-415.
[135] Martinetti, M., Tinelli, C., Kolek, V., Cuccia, M., Salvaneschi, L., Pasturenzi, L., Semenzato, G., Cipriani, A., Bartova, A. and Luisetti, M. (1995) American Journal of Respiratory and Critical Care Medicine 152, 557-564.
[136] Martusewicz-Boros, M. M., Boros, P. W., Wiatr, E., Kempisty, A., Piotrowska-Kownacka, D. and Roszkowski-Śliż, K. (2016a) Cardiac Sarcoidosis: Is it More Common in Men? Lung 194, 61-66.
[137] Martusewicz-Boros, M. M., Boros, P. W., Wiatr, E., Zych, J., Kempisty, A., Kram, M., Piotrowska-Kownacka, D., Wesołowski, S., Baughman, R. P. and Roszkowski-Sliż, K. (2019) Cardiac sarcoidosis. Medicine 98, e18037.
[138] Martusewicz-Boros, M. M., Boros, P. W., Wiatr, E., Zych, J., Piotrowska-Kownacka, D. and Roszkowski-Śliż, K. (2016b) Prevalence of cardiac sarcoidosis in white population. Medicine 95, e4518.
[139] Mc Ardle, B. A., Birnie, D. H., Klein, R., de Kemp, R. A., Leung, E., Renaud, J., DaSilva, J., Wells, G. A., Beanlands, R. S., and Nery, P. B. (2013) Is there an association between clinical presentation and the location and extent of myocardial involvement of cardiac sarcoidosis as assessed by (1)(8)F-Fluorodeoxyglucose positron emission tomography? Circulation Cardiovascular Imaging 6, 617-626.
[140] McGrath, D. S., Daniil, Z., Foley, P., du Bois, J. L., Lympany, P. A., Cullinan, P., and du Bois, R. M. (2000) Epidemiology of familial sarcoidosis in the UK. Thorax 55, 751-754.
[141] Mehta, D., Lubitz, S. A., Frankel, Z., Wisnivesky, J. P., Einstein, A. J., Goldman, M., Machac, J. and Teirstein, A. (2008) Cardiac involvement in patients with sarcoidosis. Chest 133, 1426-1435.
[142] Mehta, D., Mori, N., Goldbarg, S. H., Lubitz, S., Wisnivesky, J. P. and Teirstein, A. (2011) Primary prevention of sudden cardiac death in silent cardiac sarcoidosis: role of programmed ventricular stimulation. Circulation Arrhythmia Electrophysiology 4, 43-48.
[143] Mirsaeidi, M., Machado, R. F., Schraufnagel, D., Sweiss, N. J. and Baughman, R. P. (2015) Racial difference in sarcoidosis mortality in the United States. Chest 147, 438-449.
[144] Moller, W., Bath, W., Pohlit, W., Rust, M., Siekmeier, R., Stahlhofen, W., and Heyder, J. (1996) Smoking impairs alveolar macrophage activation after inert dust exposure. Toxicology Letters 88, 131-137.
[145] Morimoto, T., Azuma, A., Abe, S., Usuki, J., Kudoh, S., Sugisaki, K., Oritsu, M. and Nukiwa, T. (2008) Epidemiology of sarcoidosis in Japan. European Respiratory Journal 31, 372-379.
[146] Müller-Quernheim, J., Kienast, K., Held, M., Pfeifer, S. and Costabel, U. (1999) Treatment of chronic sarcoidosis with an azathioprine/ prednisolone regimen. European Respiratory Journal 14, 1117-1122.
[147] Murtagh, G., Laffin, L. J., Beshai, J. F., Maffessanti, F., Bonham, C. A., Patel, A. V., Yu, Z., Addetia, K., Mor-Avi, V., Moss, J. D., Hogarth, D. K., Sweiss, N. J., Lang, R. M.,and Patel, A. R. (2016) Prognosis in myocardial damage in sarcoidosis patients with preserved left ventricular ejection fraction: risk stratification using cardiac magnetic resonance. Circulation Cardiovascular Imaging 9, e003738.
[148] Murtagh, G., Laffin, L. J., Patel, K. V., Patel, A. V., Bonham, C. A., Yu, Z., Addetia, K., El-Hangouche, N., Maffesanti, F., Mor-Avi, V., Hogarth, D. K., Sweiss, N. J., Beshai, J. F., Lang, R. M. and Patel, A. R. (2016) Improved detection of myocardial damage in sarcoidosis using longitudinal strain in patients with preserved left ventricular ejection fraction. Echocardiography 33, 1344-1352.
[149] Muser, D., Santangeli, P., Liang, J. J., Castro, S. A., Magnani, S., Hayashi, T., Garcia, F. C., Frankel, D. S., Dixit, S., Zado, E. S., Lin, D., Desjardins, B., Callans, D. J., Alavi, A. and Marchlinski, F. E. (2018) Characterization of the electroanatomic substrate in cardiac sarcoidosis: correlation with imaging findings of scar and inflammation. JACC Clinical Electrophysiology journal 4, 291-303.
[150] Muser, D., Santangeli, P., Pathak, R. K., Castro, S. A., Liang, J. J., Magnani, S., Hayashi, T., Garcia, F. C., Hutchinson, M. D., Supple, G. E., Frankel, D. S., Riley, M. P., Lin, D., Schaller, R. D., Desjardins, B., Dixit, S., Callans, D. J., Zado, E. S. and Marchlinski, F. E. (2016) Long-term outcomes of catheter ablation of ventricular tachycardia in patients with cardiac sarcoidosis. Circulation Arrhythmia Electrophysiology 9, 113.
[151] Nadel, J., Lancefield, T., Voskoboinik, A., and Taylor, A. J. (2015) Late gadolinium enhancement identified with cardiac magnetic resonance imaging in sarcoidosis patients is associated with long-term ventricular arrhythmia and sudden cardiac death.European heart journal cardiovascular Imaging 16, 634-641.
[152] Nagai, S., Yokomatsu, T., Tanizawa, K., Ikezoe, K., Handa, T., Ito, Y., Ogino, S. and Izumi, T. (2014) Treatment with methotrexate and low-dose corticosteroids in sarcoidosis patients with cardiac lesions. Internal Medicine 53, 427-433.
[153] Nagai, T., Kohsaka, S., Okuda, S., Anzai, T., Asano, K., Fukuda, K. (2014) Incidence and prognostic significance of myocardial late gadolinium enhancement in patients with sarcoidosis without cardiac manifestation. Chest journal 146, 1064-1072.
[154] Nagai, T., Nagano, N., Sugano, Y., Asaumi, Y., Aiba, T., Kanzaki, H., Kusano, K., Noguchi, T., Yasuda, S., Ogawa, H., Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center and Anzai, T. (2015) Effect of corticosteroid therapy on long-term clinical outcome and left ventricular function in patients with cardiac sarcoidosis. Circulation Journal 79, 1593-1600.
[155] Naruse, T. K., Matsuzawa, Y., Ota, M., Katsuyama, Y., Matsumori, A., Hara, M., Nagai, S., Morimoto, S., Sasayama, S. and Inoko, H. (2000) HLA-DQB1*0601 is primarily associated with the susceptibility to cardiac sarcoidosis. Tissue Antigens 56, 52-57.
[156] Naruse, Y., Sekiguchi, Y., Nogami, A., Okada, H., Yamauchi, Y., Machino, T., Kuroki, K., Ito, Y., Yamasaki, H., Igarashi, M., Tada, H., Nitta, J., Xu, D., Sato, A. and Aonuma, K. (2014) Systematic treatment approach to ventricular tachycardia in cardiac sarcoidosis. Circulation Arrhythmia Electrophysiology 7, 407-413.
[157] Negi, M., Takemura, T., Guzman, J., Uchida, K., Furukawa, A., Suzuki, Y., Iida, T., Ishige, I., Minami, J., Yamada, T., Kawachi, H., Costabel, U. and Eishi, Y. (2012) Localization of propionibacterium acnes in granulomas supports a possible etiologic link between sarcoidosis and the bacterium. Modern Pathology 25, 1284-1297.
[158] Nery, P. B., Beanlands, R. S., Nair, G. M., Green, M., Yang, J., Mcardle, B. A., Davis, D., Ohira, H., Gollob, M. H., Leung, E., Healey, J. S. and Birnie, D. H. (2014a) Atrioventricular block as the initial manifestation of cardiac sarcoidosis in middle-aged adults. Journal of Cardiovascular Electrophysiology 25, 875-881.
[159] Nery, P. B., Keren, A., Healey, J., Leug, E., Beanlands, R. S. and Birnie, D. H. (2013) Isolated cardiac sarcoidosis: establishing the diagnosis with electroanatomic mapping-guided endomyocardial biopsy. Canadian Journal of Cardiology 29, 1015.e1-1015.e3.
[160] Nery, P. B., Mc Ardle, B. A., Redpath, C. J., Leung, E., Lemery, R., Dekemp, R., Yang, J., Keren, A., Beanlands, R. S. and Birnie, D. H. (2014b) Prevalence of cardiac sarcoidosis in patients presenting with monomorphic ventricular tachycardia. Pacing and Clinical Electrophysiology 37, 364-374.
[161] Neville, E., Walker, A. N. and James, D. G. (1983) Prognostic factors predicting the outcome of sarcoidosis: an analysis of 818 patients. The Quarterly Journal of Medicine 52, 525-533.
[162] Newman, L. S., Rose, C. S., Bresnitz, E. A., Rossman, M. D., Barnard, J., Frederick, M., Terrin, M. L., Weinberger, S. E., Moller, D. R., McLennan, G., Hunninghake, G., DePalo, L., Baughman, R. P., Iannuzzi, M. C., Judson, M. A., Knatterud, G. L., Thompson, B. W., Teirstein, A. S., Yeager, H., Johns, C. J., Rabin, D. L., Rybicki, B. A. and Cherniack, R. (2004) A Case Control Etiologic Study of Sarcoidosis. American Journal of Respiratory and Critical Care Medicine 170, 1324-1330.
[163] Nordenswan, H. K., Lehtonen, J., Ekström, K., Kandolin, R., Simonen, P., Mäyränpää, M., Vihinen, T., Miettinen, H., Kaikkonen, K., Haataja, P., Kerola, T., Rissanen, T. T., Kokkonen, J., Alatalo, A., Pietilä-Effati, P., Utriainen, S. and Kupari. M. (2018) Outcome of cardiac sarcoidosis presenting with high-grade atrioventricular block. Circulation Arrhythmia Electrophysiology 11, e006145.
[164] Oe, Y., Department of Pathology National Cerebral and Cardiovascular Center Osaka Japan, Ishibashi‐Ueda, H., Matsuyama, T., Kuo, Y., Nagai, T., Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center Osaka Japan, Ikeda, Y., Ohta‐Ogo, K., Noguchi, T., Anzai, T. and Department of Cardiovascular Medicine National Cerebral and Cardiovascular Center Osaka Japan. (2019) Lymph vessel proliferation on cardiac biopsy may help in the diagnosis of cardiac sarcoidosis. Journal of the American Heart Association 8.
[165] Ohira, H., Tsujino, I., Ishimaru, S., Oyama, N., Takei, T., Tsukamoto, E., Miura, M., Sakaue, S., Tamaki, N. and Nishimura, M. (2008) Myocardial imaging with 18F-fluoro-2-deoxyglucose positron emission tomography and magnetic resonance imaging in sarcoidosis. European Journal of Nuclear Medicine and Molecular Imaging 35, 933-941.
[166] Okada, D. R., Bravo, P. E., Vita, T., Agarwal, V., Osborne, M. T., Taqueti, V. R., Skali, H., Chareonthaitawee, P., Dorbala, S., Stewart, G., Di Carli, M., and Blankstein, R. (2016) Isolated cardiac sarcoidosis: a focused review of an under-recognized entity [published correction appears in J Nucl Cardiol. 2016 Sep 28;]. Journal of Nuclear Cardiology 25, 1136-1146.
[167] Okada, D. R., Smith, J., Derakhshan, A., Gowani, Z., Zimmerman, S. L., Misra, S., Berger, R. D., Calkins, H., Tandri, H. and Chrispin, J. (2019) Electrophysiology study for risk stratification in patients with cardiac sarcoidosis and abnormal cardiac imaging. International Journal of Cardiology Heart and Vasculature 23, 100342.
[168] Okada, D. R., Smith, J., Derakhshan, A., Gowani, Z.,Misra, S.and Berger, R. D. (2018) Ventricular arrhythmias in cardiac sarcoidosis. Circulation 138, 1253-1264.
[169] Okumura, W., Iwasaki, T., Toyama, T., Iso, T., Arai, M., Oriuchi, N., Endo, K., Yokoyama, T., Suzuki, T. and Kurabayashi, M. (2004) Usefulness of fasting 18F-FDG PET in identification of cardiac sarcoidosis. Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine 45, 1989-1998.
[170] Orii, M., Hirata, K., Tanimoto, T., Ota, S., Shiono, Y., Yamano, T., Matsuo, Y., Ino, Y., Yamaguchi, T., Kubo, T., Tanaka, A. and Akasaka, T. (2015) Comparison of cardiac MRI and 18F-FDG positron emission tomography manifestations and regional response to corticosteroid therapy in newly diagnosed cardiac sarcoidosis with complete heart block. Heart Rhythm journal 12, 2477-2485.
[171] Osborne, M. T., Hulten, E. A., Murthy, V. L., Skali, H., Taqueti, V. R., Dorbala, S., DiCarli, M. F., and Blankstein, R. (2017) Patient preparation for cardiac fluorine-18 fluorodeoxyglucose positron emission tomography imaging of inflammation. Journal of Nuclear Cardiology 24, 86‐99.
[172] Padala, S. K., Peaslee, S., Sidhu, M. S., Steckman, D. A. and Judson, M. A. (2017) Impact of early initiation of corticosteroid therapy on cardiac function and rhythm in patients with cardiac sarcoidosis. International Journal of Cardiology 227, 565-570.
[173] Papageorgiou, N., Providência, R., Bronis, K., Dechering, D. G., Srinivasan, N. and Eckardt, L. (2018) Catheter ablation for ventricular tachycardia in patients with cardiac sarcoidosis: a systematic review. Europace journal 20, 682-691.
[174] Parkes, S. A., Baker, S. B., Bourdillon, R. E., Murray, C. R., Rakshit, M., Sarkies, J. W., Travers, J. P. and Williams, E. W. (1985) Incidence of sarcoidosis in the Isle of man. Thorax 40, 284-287.
[175] Pasadhika, S. and Rosenbaum, J. T. (2015) Ocular sarcoidosis. Clinics in Chest Medicine 36, 669-683.
[176] Patel, A. R., Klein, M. R., Chandra, S., Spencer, K.T., Decara, J. M., Lang, R. M., Burke, M. C., Garrity, E. R., Hogarth, K. D., Archer, S. L., Sweiss, N. J., and Beshai, J. F. (2011) Myocardial damage in patients with sarcoidosis and preserved left ventricular systolic function: an observational study. European Journal of Heart Failure 13, 1231-1237.
[177] Patel, M. R., Cawley, P. J., Heitner, J. F., Klem, I., Parker, M. A., Jaroudi, W. A., Meine, T. J., White, J. B., Elliott, M. D., Kim, H. W., Judd, R. M. and Kim, R. J. (2009) Detection of myocardial damage in patients with sarcoidosis. Circulation 120, 1969-1977.
[178] Patel, N., Kalra, R., Doshi, R., Arora, H., Bajaj, N. S., Division of Cardiovascular Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, Department of Radiology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, Arora, G., Arora, P. and Section of Cardiology, Birmingham Veterans Affairs Medical Center, Birmingham, AL (2018) Hospitalization rates, prevalence of cardiovascular manifestations, and outcomes associated with sarcoidosis in the United States. Journal of the American Heart Association 7.
[179] Pellegrino, D., Bonab, A. A., Dragotakes, S. C., Pitman, J. T., Mariani, G., Carter, E. A. (2005) Inflammation and infection: imaging properties of 18F-FDG-labeled white blood cells versus 18F-FDG. Journal of Nuclear Medicine 46, 1522-1530.
[180] Pereira, C. A. C., Dornfeld, M. C., Baughman, R. and Judson, M. A. (2014) Clinical phenotypes in sarcoidosis. Current Opinion in Pulmonary Medicine 20, 496-502.
[181] Perry, A. and Vuitch, F. (1995) Causes of death in patients with sarcoidosis. A morphologic study of 38 autopsies with clinicopathologic correlations. Archives of Pathology &Amp; Laboratory Medicine 119, 167-172.
[182] Pierre-Louis, B., Prasad, A. and Frishman, W. H. (2009) Cardiac Manifestations of Sarcoidosis and Therapeutic Options. Cardiology in Review 17, 153-158.
[183] Pietinalho, A., Ohmichi, M., Hiraga, Y., Löfroos, A. B. and Selroos, O. (1996) The mode of presentation of sarcoidosis in Finland and Hokkaido, Japan. A comparative analysis of 571 Finnish and 686 Japanese patients. Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG 13, 159-166.
[184] Pizarro, C., Goebel, A., Dabir, D., Hammerstingl, C., Pabst, S., Grohé, C., Fimmers, R., Stoffel-Wagner, B., Nickenig, G., Schild, H., Skowasch, D., Thomas, D. (2016) Cardiovascular magnetic resonance-guided diagnosis of cardiac affection in a Caucasian sarcoidosis population. Sarcoidosis Vasculitis and Diffuse Lung Diseases journal 32, 325-335.
[185] Prasse, A., Katic, C., Germann, M., Buchwald, A., Zissel, G. and Müller-Quernheim, J. (2008) Phenotyping Sarcoidosis from a Pulmonary Perspective. American Journal of Respiratory and Critical Care Medicine 177, 330-336.
[186] Procaccini, C., Jirillo, E. and Matarese, G. (2012) Leptin as an immunomodulator. Molecular Aspects of Medicine 33, 35-45.
[187] Protonotarios, A., Wicks, E., Ashworth, M., Stephenson, E., Guttmann, E., Savvatis, K., Sekhri, N., Mohiddin, S. A., Syrris, P., Menezes, L. and Elliott, P. (2019) Prevalence of 18F-fluorodeoxyglucose positron emission tomography abnormalities in patients with arrhythmogenic right ventricular cardiomyopathy. International Journal of Cardiology 284, 99-104.
[188] Puntmann, V. O., Isted, A., Hinojar, R., Foote, L., Carr-White, G., and Nagel, E. (2017) T1 and T2 mapping in recognition of early cardiac involvement in systemic sarcoidosis. Radiology 285, 63-72.
[189] Rabin, D. L. (2004) Sarcoidosis: social predictors of severity at presentation. European Respiratory Journal 24, 601-608.
[190] Rabin, D. L., Richardson, M. S. A., Stein, S. R. and Yeager Jr, H. (2001) Sarcoidosis severity and socioeconomic status. European Respiratory Journal 18, 499-506.
[191] Rao, D. A. and Dellaripa, P. F. (2013) Extrapulmonary manifestations of sarcoidosis. Rheumatic Disease Clinics of North America 39, 277-297.
[192] Reynolds, H. Y. (2002) Sarcoidosis: impact of other illnesses on the presentation and management of multi-organ disease. Lung 180, 281-299.
[193] Rivera, N. V., Ronninger, M., Shchetynsky, K., Franke, A., Nöthen, M. M., Müller-Quernheim, J., Schreiber, S., Adrianto, I., Karakaya, B., van Moorsel, C. H. M., Navratilova, Z., Kolek, V., Rybicki, B. A., Iannuzzi, M. C., Petrek, M., Grutters, J. C., Montgomery, C., Fischer, A., Eklund, A., Padyukov, L. and Grunewald, J. (2016) High-Density Genetic mapping identifies new susceptibility variants in sarcoidosis phenotypes and shows genomic-driven phenotypic differences. American Journal of Respiratory and Critical Care Medicine 193, 1008-1022.
[194] Roberts, W. C., McAllister, H. A., and Ferrans, V. J. (1977) Sarcoidosis of the heart: a clinicopathologic study of 35 necropsy patients (group I) and review of 78 previously described necropsy patients (group II). American Journal of Medicine 63, 86-108.
[195] Rosenthal, D. G., Cheng, R. K., Petek, B. J., Masri, S. C., Mikacenic, C., Raghu, G. and Patton, K. K. (2020) Risk of adverse cardiovascular events in cardiac sarcoidosis independent of left ventricular function. American Journal of Cardiology 127, 142-148.
[196] Rosenthal, D. G., Parwani, P., Murray, T. O., Petek, B. J., Benn, B. S., De Marco, T., Gerstenfeld, E. P., Janmohamed, M., Klein, L., Lee, B. K., Moss, J. D., Scheinman, M. M., Hsia, H. H., Selby, V., Koth, L. L., Pampaloni, M. H., Zikherman, J. and Vedantham, V. (2019) Long-term corticosteroid-sparing immunosuppresion for cardiac sarcoidosis. Journal of the American Heart Association 8, e010952.
[197] Rossman, M. D., Thompson, B., Frederick, M., Maliarik, M., Iannuzzi, M. C., Rybicki, B. A., Pandey, J. P., Newman, L. S., Magira, E., Beznik-Cizman, B. and Monos, D. (2003) HLA-DRB1*1101: A Significant Risk Factor for Sarcoidosis in Blacks and Whites. The American Journal of Human Genetics 73, 720-735.
[198] Rybicki, B. A., and the SAGA Study Consortium, Sinha, R., Iyengar, S., Gray-McGuire, C., Elston, R. C. and Iannuzzi, M. C. (2007) Genetic linkage analysis of sarcoidosis phenotypes: the sarcoidosis genetic analysis (SAGA) study. Genes & Immunity 8, 379-386.
[199] Rybicki, B. A., Major, M., Popovich, J., Maliank, M. J. and lannuzzi, M. C. (1997) Racial differences in sarcoidosis incidence: A 5-Year study in a health maintenance organization. American Journal of Epidemiology 145, 234-241.
[200] Rybicki, B. A., Maliarik, M. J., Poisson, L. M., Sheffer, R., Chen, K. M., Major, M., Chase, G. A. and Iannuzzi, M. C. (2003) The major histocompatibility complex gene region and sarcoidosis susceptibility in African Americans. American Journal of Respiratory and Critical Care Medicine 167, 444-449.
[201] Rybicki, B. and Iannuzzi, M. (2007) Epidemiology of sarcoidosis: Recent advances and future prospects. Seminars in Respiratory and Critical Care Medicine 28, 022-035.
[202] Sadek, M. M., Yung, D., Birnie, D. H., Beanlands, R. S. and Nery, P. B. (2013) Corticosteroid therapy for cardiac sarcoidosis: a systematic review. Canadian Journal of Cardiology 29, 1034-1041.
[203] Sakthivel, P. and Bruder, D. (2017) Mechanism of granuloma formation in sarcoidosis. Current Opinion in Hematology 24, 59-65.
[204] Sato, H., Woodhead, F. A., Ahmad, T., Grutters, J. C., Spagnolo, P., van den Bosch, J. M. M., Maier, L. A., Newman, L. S., Nagai, S., Izumi, T., Wells, A. U., du Bois, R. M. and Welsh, K. I. (2010) Sarcoidosis HLA class II genotyping distinguishes differences of clinical phenotype across ethnic groups. Human Molecular Genetics 19, 4100-4111.
[205] Sawahata, M., Sugiyama, Y., Nakamura, Y., Nakayama, M., Mato, N., Yamasawa, H. and Bando, M. (2015) Age-related and historical changes in the clinical characteristics of sarcoidosis in Japan. Respiratory Medicine 109, 272-278.
[206] Schuller, J. L., Olson, M. D., Zipse, M. M., Schneider, P. M., Aleong, R. G., Wienberger, H. D., Varosy, P. D. and Sauer, W. H. (2011) Electrocardiographic characteristics in patients with pulmonary sarcoidosis indicating cardiac involvement. Journal of Cardiovascular Electrophysiology 22, 1243-1248.
[207] Schuller, J. L., Zipse, M., Crawford, T., Bogun, F., Beshai, J., Patel, A. R., Sweiss, N. J., Nguyen, D. T., Aleong, R. G., Varosy, P. D., Weinberger, H. D. and Sauer, W. H. (2012) Implantable cardioverter defibrillator therapy in patients with cardiac sarcoidosis. Journal of Cardiovascular Electrophysiology 23, 925-929.
[208] Schupp, J. C., Freitag-Wolf, S., Bargagli, E., Mihailović-Vučinić, V., Rottoli, P., Grubanovic, A., Müller, A., Jochens, A., Tittmann, L., Schnerch, J., et al. (2018) Phenotypes of organ involvement in sarcoidosis. European Respiratory Journal 51, 1700991.
[209] Schurmann, M., Lympany, P. A., Reichel, P., Muller-Myhsok, B., Wurm, K., Schlaak, M., Muller-Quernheim, J., du Bois, R. M., and Schwinger, E. (2000) Familial sarcoidosis is linked to the major histocompatibility complex region. American Journal of Respiratory and Critical Care Medicine 162, 861-864.
[210] Schurmann, M., Reichel, P., Muller-Myhsok, B., Schlaak, M., Muller-Quernheim, J., and Schwinger, E. (2001) Results from a genome-wide search for predisposing genes in sarcoidosis. American Journal of Respiratory and Critical Care Medicine 164, 840-846.
[211] Schutt, A. C., Bullington, W. M. and Judson, M. A. (2010) Pharmacotherapy for pulmonary sarcoidosis: a Delphi consensus study. Respiratory Medicine 104, 717-723.
[212] Segawa, M., Fukuda, K., Nakano, M., Kondo, M., Satake, H., Hirano, M. and Shimokawa, H. (2016) Time course and factors correlating with ventricular tachyarrhythmias after introduction of steroid therapy in cardiac sarcoidosis. Circulation Arrhythmia Electrophysiology 9, e003353.
[213] Selroos, O. (1969) The frequency, clinical picture and prognosis of pulmonary sarcoidosis in Finland. Acta Medica Scandinavica Supplement 503, 3-73.
[214] Shafee, M. A., Fukuda, K., Wakayama, Y., Nakano, M., Kondo, M., Hasebe, Y., Kawana, A., and Shimokawa, H. (2012) Delayed enhancement on cardiac magnetic resonance imaging is a poor prognostic factor in patients with cardiac sarcoidosis. Journal of Cardiology 60, 448-453.
[215] Siltzbach, L. E., James, D. G., Neville, E., Turiaf, J., Battesti, J. P., Sharma, O. P., Hosoda, Y., Mikami, R. and Odaka, M. (1974) Course and prognosis of sarcoidosis around the world. The American Journal of Medicine 57, 847-852.
[216] Silverman, K. J., Hutchins, G. M. and Bulkley, B. H. (1978) Cardiac sarcoid: a clinicopathologic study of 84 unselected patients with systemic sarcoidosis. Circulation 58, 1204-1211.
[217] Silverstein, M. D., Lashner, B. A. and Hanauer, S. B. (1994) Cigarette smoking and ulcerative colitis: A case-control study. Mayo Clinic Proceedings 69, 425-429.
[218] Skold, C. M., Larsen, F. F., Rasmussen, E., Pehrsson, S. K. and Eklund, A. G. (2002) Determination of cardiac involvement in sarcoidosis by magnetic resonance imaging and Doppler echocardiography. Journal of Internal Medicine 252, 465-471.
[219] Slart, R. H., Glaudemans, A. W., Lancellotti, P., and Writing group; Document reading group; EACVI Reviewers: This document was reviewed by members of the EACVI Scientific Documents Committee for 2014-2016 and 2016-2018. (2017) A joint procedural position statement on imaging in cardiac sarcoidosis: from the Cardiovascular and Inflammation and Infection Committees of the European Association of Nuclear Medicine, the European Association of Cardiovascular Imaging, and the American Society of Nuclear Cardiology. European Heart Journal of Cardiovascular Imaging 18, 1073-1089.
[220] Smedema, J. P., van Geuns, R. J., Ainslie, G., Ector, J., Heidbuchel, H., Crijns, H. J. GM. (2017) Right ventricular involvement in cardiac sarcoidosis demonstrated with cardiac magnetic resonance. ESC Heart Failure 4, 535‐544.
[221] Smedema, J., Snoep, G., van Kroonenburgh, M. P. G., van Geuns, R., Dassen, W. R. M., Gorgels, A. P. M. and Crijns, H. J. G. M. (2005) Evaluation of the accuracy of gadolinium-enhanced cardiovascular magnetic resonance in the diagnosis of cardiac sarcoidosis. Journal of the American College of Cardiology 45, 1683-1690.
[222] Smith, M. J., Turton, C. W., Mitchell, D. N., Turner-Warwick, M., Morris, L. M. and Lawler, S. D. (1981) Association of HLA B8 with spontaneous resolution in sarcoidosis. Thorax 36, 296-298.
[223] Soejima, K. and Yada, H. (2009) The Work-Up and management of patients with apparent or subclinical cardiac sarcoidosis: with emphasis on the associated heart rhythm abnormalities. Journal of Cardiovascular Electrophysiology 20, 578-583.
[224] Sohn, D. W., Park, J. B., Lee, S. P., Kim, H. K. and Kim, Y. J. (2018) Viewpoints in the diagnosis and treatment of cardiac sarcoidosis: proposed modification of current guidelines. Clinical Cardiology 41, 1386-1394.
[225] Spagnolo, P. and Grunewald, J. (2013) Recent advances in the genetics of sarcoidosis. Journal of Medical Genetics 50, 290-297.
[226] Sperry, B. W., Tamarappoo, B. K., Oldan, J. D., Javed, O., Culver, D. A., Brunken, R., Cerqueira, M. D. and Hachamovitch, R. (2018) Prognostic impact of extent, severity, and heterogeneity of abnormalities on (18) F-FDG PET scans for suspected cardiac sarcoidosis. JACC Cardiovascular Imaging 11, 336-345.
[227] Steckman, D. A., Schneider, P. M., Schuller, J. L., Aleong, R. G., Nguyen, D. T., Sinagra, G., Vitrella, G., Brun, F., Cova, M. A., Pagnan, L., Mestroni, L., Varosy, P. D. and Sauer, W. (2012) Utility of cardiac magnetic resonance imaging to differentiate cardiac sarcoidosis from arrhythmogenic right ventricular cardiomyopathy. American Journal of Cardiology 110, 575-579.
[228] Stees, C. S., Khoo, M. S. C., Lowery, C. M. and Sauer, W. H. (2011) Ventricular tachycardia storm successfully treated with immunosuppression and catheter ablation in a patient with cardiac sarcoidosis. Journal of Cardiovascular Electrophysiology 22, 210-213.
[229] Sun, B. J., Lee, P. H., Choi, H. O., Ahn, J., Seo, J., Kim, D., Song, J., Choi, K. J., Kang, D. and Song, J. (2011) Prevalence of echocardiographic features suggesting cardiac sarcoidosis in patients with pacemaker or implantable cardiac defibrillator. Korean Circulation Journal 41, 313.
[230] Suzuki, T., Kanda, T., Kubota, S., Imai, S. and Murata, K. (1994) Holter monitoring as a noninvasive indicator of cardiac involvement in sarcoidosis. Chest journal 106, 1021-1024.
[231] Swigris, J. J., Olson, A. L., Huie, T. J., Fernandez-Perez, E. R., Solomon, J., Sprunger, D. and Brown, K. K. (2011) Sarcoidosis-related Mortality in the United States from 1988 to 2007. American Journal of Respiratory and Critical Care Medicine 183, 1524-1530.
[232] Ten Berge, B., Paats, M. S., Bergen, I. M., Van Den Blink, B., Hoogsteden, H. C., Lambrecht, B. N., Hendriks, R. W. and KleinJan, A. (2012) Increased IL-17A expression in granulomas and in circulating memory T cells in sarcoidosis. Rheumatology 51, 37-46.
[233] Terasaki, F., and Yoshinaga, K. (2017) New guidelines for diagnosis of cardiac sarcoidosis in Japan. Annals of Nuclear Cardiology 3, 42-45.
[234] Terasaki, F., Azuma, A., Anzai, T., Ishizaka, N., Ishida, Y., Isobe, M., Inomata, T., Ishibashi-Ueda, H., Eishi, Y., Kitakaze, M., et al. (2019) JCS 2016 Guideline on diagnosis and treatment of cardiac sarcoidosis ― Digest version ―. Circulation Journal 83, 2329-2388.
[235] Thomeer, M., Demedts, M., Vandeurzen, K. and VRGT Working group on Interstitial Lung Diseases. (2001) Registration of interstitial lung diseases by 20 centres of respiratory medicine in flanders. Acta Clinica Belgica 56, 163-172.
[236] Towbin, J. A., McKenna, W. J., Abrams, D. J., Ackerman, M. J., Calkins, H., Darrieux, F. C. C., Daubert, J. P., de Chillou, C., DePasquale, E. C., Desai, M. Y., Estes, N. A. M. 3r⁢d., Hua, W., Indik, J. H., Ingles, J., James, C. A., John, R. M., Judge, D. P., Keegan, R., Krahn, A. D., Link, M. S., Marcus, F. I., McLeod, C. J., Mestroni, L., Priori, S. G., Saffitz, J. E., Sanatani, S., Shimizu, W., van Tintelen, J. P., Wilde, A. A. M., and Zareba, W. et al. (2019) 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy. Heart Rhythm journal 16, e301-e372.
[237] Tung, R., Bauer, B., Schelbert, H., Lynch 3r⁢d, J. P., Auerbach, M., Gupta, P., Schiepers, C., Chan, S., Ferris, J., Barrio, M., Ajijola, O., Bradfield, J., and Shivkumar, K. (2015) Incidence of abnormal positron emission tomography in patients with unexplained cardiomyopathy and ventricular arrhythmias: the potential role of occult inflammation in arrhythmogenesis. Heart Rhythm journal 12, 2488-2498.
[238] Uemura, A., Morimoto, S., Hiramitsu, S., Kato, Y., Ito, T. and Hishida, H. (1999) Histologic diagnostic rate of cardiac sarcoidosis: Evaluation of endomyocardial biopsies. American Heart Journal 138, 299-302.
[239] Ungprasert, P., Carmona, E. M., Utz, J. P., Ryu, J. H., Crowson, C. S. and Matteson, E. L. (2016a) Epidemiology of sarcoidosis 1946-2013. Mayo Clinic Proceedings 91, 183-188.
[240] Ungprasert, P., Crowson, C. S. and Matteson, E. L. (2016b) Seasonal variation in incidence of sarcoidosis: a population-based study, 1976-2013. Thorax 71, 1164-1166.
[241] Ungprasert, P., Crowson, C. S. and Matteson, E. L. (2017a) Epidemiology and clinical characteristics of sarcoidosis: an update from a population-based cohort study from Olmsted County, Minnesota. Reumatismo 69, 16.
[242] Ungprasert, P., Crowson, C. S. and Matteson, E. L. (2017b) Influence of gender on epidemiology and clinical manifestations of sarcoidosis: a population-based retrospective cohort study 1976-2013. Lung 195, 87-91.
[243] Uthman, I., Touma, Z, and Khoury, M. (2007) Cardiac sarcoidosis responding to monotherapy with infliximab. Clinical Rheumatology 26, 2001-2003.
[244] Valeyre, D., Soler, P., Clerici, C., Pre, J., Battesti, J. P., Georges, R. and Hance, A. J. (1988) Smoking and pulmonary sarcoidosis: effect of cigarette smoking on prevalence, clinical manifestations, alveolitis, and evolution of the disease. Thorax 43, 516-524.
[245] Verleden, G. M., du Bois, R. M., Bouros, D., Drent, M., Millar, A., Müller-Quernheim, J, Semenzato, G., Johnson, S., Sourvino. G., Olivier, D., Pietinalho, A., and Xaubet, A. (2001) Genetic predisposition and pathogenetic mechanisms of interstitial lung diseases of unknown origin. European Respiratory Journal, Supplement 32, 17s-29s.
[246] Vignaux, O., Dhote, R., Duboc, D., Blanche, P., Devaux, J. Y., Weber, S. and Legmann, P. (2002) Detection of myocardial involvement in patients with sarcoidosis applying T2-weighted, contrast-enhanced, and cine magnetic resonance imaging initial results of a prospective study. Journal of Computer Assisted Tomography 26, 762-767.
[247] Vihlborg, P., Bryngelsson, I., Andersson, L. and Graff, P. (2017) Risk of sarcoidosis and seropositive rheumatoid arthritis from occupational silica exposure in Swedish iron foundries: a retrospective cohort study. Bmj Open 7, e016839.
[248] Viskum, K. and Vestbo, J. (1993) Vital prognosis in intrathoracic sarcoidosis with special reference to pulmonary function and radiological stage. The European Respiratory Journal 6, 349-353.
[249] Voortman, M., Hendriks, C. M. R., Elfferich, M. D. P., Bonella, F., Moller, J., De Vries, J., Costabel, U. and Drent, M. (2019) The burden of sarcoidosis symptoms from a patient perspective. Lung 197, 155-161.
[250] Vorselaars, A. D. M., van Moorsel, C. H. M., Zanen, P., Ruven, H. J. T., Claessen, A. M. E., van Velzen-Blad, H. and Grutters, J. C. (2015) ACE and sIL-2R correlate with lung function improvement in sarcoidosis during methotrexate therapy. Respiratory Medicine 109, 279-285.
[251] White, J. A., Rajchl, M., Butler, J., Thompson, T. R., Prato, F. S., and Wisenberg, G. (2013) Active cardiac sarcoidosis: first clinical experience of simultaneous positron emission tomography— magnetic resonance imaging for the diagnosis of cardiac disease. Circulation 127, 639-641.
[252] Wicks, E. C., Menezes, L. J., Barnes, A., Mohiddin, S. A., Sekhri, N., Porter, J. C., Booth, H. L., Garrett, E., Patel, R. S., Pavlou, M., Groves, A. M., and Elliott, P. M. (2018) Diagnostic accuracy and prognostic value of simultaneous hybrid 18 F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging in cardiac sarcoidosis. European Heart Journal of Cardiovascular Imaging 19, 757-767.
[253] Wozniak, S. E., Gee, L. L., Wachtel, M. S. and Frezza, E. E. (2009) Adipose tissue: The new endocrine organ? A review article. Digestive Diseases and Sciences 54, 1847-1856.
[254] Xiao, L., Kookana, A., McClure, R. and Heraganahally, S. (2018) Sarcoid-resembling granulomatous lung disease secondary to occupational magnetite iron dust exposure. Respirology Case Reports 6, e00331.
[255] Yalagudri, S., Zin, T. N., Devidutta, S., Saggu, D., Thachil, A, and Chennapragada, S. (2017) Tailored approach for management of ventricular tachycardia in cardiac sarcoidosis. Journal of Cardiovascular Electrophysiology 28, 893-902.
[256] Yamamoto, M., Sharma, O. P., and Hosoda, Y. (1992) The 1991 descriptive definition of sarcoidosis. In Proceedings of the XII world congress on sarcoidosis. Sarcoidosis 9, 33-34.
[257] Yanardag, H., Pamuk, N. and Karayel, T. (2003) Cutaneous involvement in sarcoidosis: analysis of the features in 170 patients. Respiratory Medicine 97, 978-982.
[258] Yanardag, H., Tetikkurt, C., Bilir, M., Demirci, S. and Iscimen, A. (2013) Diagnosis of cutaneous sarcoidosis; clinical and the prognostic significance of skin lesions. Multidisciplinary Respiratory Medicine 8, 26-31.
[259] Yasuda, M., Iwanaga, Y., Kato, T., Izumi, T., Inuzuka, Y., Nakamura, T., Miyaji, Y., Kawamura, T., Ikeguchi, S., Inoko, M., Kurita, T., and Miyazaki, S. (2016) Risk stratification for major adverse cardiac events and ventricular tachyarrhythmia’s by cardiac MRI in patients with sarcoidosis. Open Heart journal 3, e000437.
[260] Yazaki, Y., Isobe, M., Hiroe, M., Morimoto, S., Hiramitsu, S., Nakano, T., Izumi, T. and Sekiguchi, M. (2001) Prognostic determinants of long-term survival in Japanese patients with cardiac sarcoidosis treated with prednisone. The American Journal of Cardiology 88, 1006-1010.
[261] Yodogawa, K., Seino, Y., Ohara, T., Iwasaki, Y., Hayashi, M., Miyauchi, Y., Azuma, A. and Shimizu, W. (2018) Prognostic significance of ventricular late potentials in patients with pulmonary sarcoidosis. Heart Rhythm 15, 798-802.
[262] Youssef, G., Beanlands, R. S. B., Birnie, D. H. and Nery, P. B. (2011) Cardiac sarcoidosis: applications of imaging in diagnosis and directing treatment. Heart 97, 2078-2087.
[263] Youssef, G., Leung, E., Mylonas, I., Nery, P., Williams, K., Wisenberg, G., Gulenchyn, K. Y., Dekemp, R. A., Dasilva, J., Birnie, D., Wells, G. A., and Beanlands, R. S. (2012) The use of 18F-FDG PET in the diagnosis of cardiac sarcoidosis: a systematic review and metaanalysis including the Ontario experience. Journal of Nuclear Medicine 53, 241-248.
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