Special Issues

Special Issue Title: Immune cell behavior

· Print Special Issue Flyer

· Deadline for manuscript submissions:  1 April 2020 

Special Issue Editor

Guest Editor

Prof. Dr. Yusof Kamisah

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia

Website | E-Mail

Interests: Roles of natural products on immune cells and inflammation in cardiac hypertrophy and hypertension

Special Issue Information

Dear Colleagues,

Immune system is an essential component in our body that protects us against invasion into our body, to guarantee our survival. The most important immune cells in our system are the white blood cells which include phagocytes and lymphocytes. In cardiovascular system, damage to the organs will trigger inflammatory response, orchestrated by immune cells. Disturbances to the immune system may cause inflammation related cardiovascular disease such as atherosclerosis, myocardial infarction, hypertension and many others.
The main focus of the Special Issue on Immune Cell Behavior is to comprehensively review the role of immune cell behavior in cardiovascular disease, and its possible modulation by drugs and potential phytochemicals. 
Topics of interests for the planned Special Issue of Reviews in Cardiovascular Medicine include but not limited to:
1. Molecular mechanisms of immune cell behavior in cardiovascular disease.
2. Modulation of immune cell behavior by phytochemicals in cardiovascular disease.
3. Modulation of immune cell behavior by cardiovascular drugs.
4. Role of transcription factors in cardiovascular immune system.
5. Role of immune cells in inflammatory response in cardiovascular disease.
6. Immune cells-targeted therapy in cardiovascular disease
The overall goal of this Special Issue is to provide more understanding to readers regarding the behavior of the immune cells that play a role in cardiovascular disease.
Authors are invited to submit their reviews, original research articles, systematic reviews, case reports and short communications to the special issue.

Prof. Dr. Yusof Kamisah

Guest Editor


Manuscript Submission Information

Manuscripts should be submitted online at https://rcm.imrpress.org by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Reviews in Cardiovascular Medicine is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is $1950. Submitted papers should be well formatted and use good English.


Monocytes; lymphocytes; Clinical trials; Animal studies; In vitro studies; Inflammation; Immune system; Myocardial disease; Cardiorenal syndromes; Atherosclerosis; Hypertension 

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Antioxidative and anti-inflammatory activities of Polygonum minus: a review of literature
Adila A Hamid, Amilia Aminuddin, Mohd Heikal Mohd Yunus, Jaya Kumar Murthy, Chua Kien Hui, Azizah Ugusman
Reviews in Cardiovascular Medicine    2020, 21 (2): 275-287.   DOI: 10.31083/j.rcm.2020.02.50
Abstract589)   HTML54)    PDF(pc) (1539KB)(901)       Save
Inflammation and oxidative stress are involved in the pathogenesis of cardiovascular diseases such as atherosclerosis, hypertension and ischemic heart disease. Natural products play an important role as nutritional supplements with potential health benefits in cardiovascular diseases. Polygonum minus (PM) is an aromatic plant that is widely used as a flavoring agent in cooking and has been recognized as a plant with various medicinal properties including antioxidative and anti-inflammatory actions. Phytoconstituents found in PM such as phenolic and flavonoid compounds contribute to the plant's antioxidative and anti-inflammatory effects. We conducted this review to systematically identify articles related to the antioxidative and anti-inflammatory activities of PM. A computerized database search was conducted on Ovid MEDLINE, PubMed, Scopus, and ACS publication, from 1946 until May 2020, and the following keywords were used: ‘Kesum OR Polygonum minus OR Persicaria minor' AND ‘inflammat* OR oxida* OR antioxida*'. A total of 125 articles were obtained. Another eight additional articles were identified through Google Scholar and review articles. Altogether, 17 articles were used for data extraction, comprising 16 articles on antioxidant and one article on anti-inflammatory activity of PM. These studies consist of 14 in vitro studies, one in vivo animal study, one combined in vitro and in vivo study and one combined in vitro and ex vivo study. All the studies reported that PM exhibits antioxidative and anti-inflammatory activities which are most likely attributed to its high phenolic and flavonoid content.
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Implication of dietary phenolic acids on inflammation in cardiovascular disease
Shafreena Shaukat Ali, Wan Amir Nizam Wan Ahmad, Siti Balkis Budin, Satirah Zainalabidin
Reviews in Cardiovascular Medicine    2020, 21 (2): 225-240.   DOI: 10.31083/j.rcm.2020.02.49
Abstract567)   HTML67)    PDF(pc) (1447KB)(1127)       Save
In spite of medical advances, cardiovascular disease remains a significant concern, imposing a great burden upon the economy and public health of nations by causing the highest morbidity and mortality cases globally. Moreover, it is well established that inflammation is closely linked to the pathogenesis of cardiovascular diseases. Hence, targeting inflammation seems to be a promising strategy in reducing cardiovascular risks. Currently, the importance of natural products in modern medicine is well recognised and continues to be of interest to the pharmaceutical industry. Phenolic acids are a class of phytochemical compounds that are well-known for their health benefits. They consists of various phytochemical constituents and have been widely studied in various disease models. Research involving both animals and humans has proven that phenolic acids possess cardioprotective properties such as anti-hypertensive, anti-hyperlipidemia, anti-fibrotic and anti-hypertrophy activity. Furthermore, numerous studies have proven that phenolic acids in phytochemical constituents such as gallic acid, caffeic acid and chlorogenic acid are promising anti-inflammatory agents. Hence, in this review, we outline and review recent evidence on the role of phenolic acids and their anti-inflammatory significance in studies published during the last 5 years. We also discuss their possible mechanisms of action in modulating inflammation related to cardiovascular disease.
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