Special Issues

Special Issue Title: Sudden cardiac death

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· Deadline for manuscript submissions: 1 August 2020

Special Issue Editor

Guest Editor

       Prof. Dr. Cristina Balla

       Cardiology Department, University of Ferrara, Italy

Website | E-Mail

Interests: Sudden cardiac death; Brugada syndrome; Arrhythmias

Special Issue Information

Dear Colleagues,

Sudden cardiac death (SCD) remains one of the most challenging tasks in Cardiology, accounting for 15-20% of deaths. SCDs have mostly arrhythmic origin and is linked to a variety of cardiac conditions such as coronary artery disease, heart failure, cardiomyopathies or cardiac channelopathies. Severe left ventricular systolic dysfunction (left ventricular ejection fraction LVEF < 35%) and reduced functional capacity are the principal discriminators to stratify the risk of SCD, independently from the etiology of the myocardial disease. Implantable cardioverter defibrillators (ICD) are the most effective therapy to reduce SCD. However, despite the progress in cardiovascular therapies, one half of SCDs occurs in patients without any known cardiac disease, and even when a cardiac disorder has been diagnosed before, in the large majority of SCDs, our capability to predict the risk is limited. Therefore, the aim of this special issue is to highlights novel diagnostic approaches to better manage and stratify patients at risk of SCD and to focus on innovative therapies in this field. We are welcoming Research articles, Case reports, Reviews and Metanalysis on all aspects of research into SCD from preclinical and translational investigations of the underlying molecular and genetic mechanisms, to clinical observations and epidemiological studies.

Prof. Dr. Cristina Balla

Guest Editor


Manuscript Submission Information

Manuscripts should be submitted online at https://rcm.imrpress.org by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Reviews in Cardiovascular Medicine is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is $1950. Submitted papers should be well formatted and use good English.


Sudden cardiac death; Implantable cardioverter defibrillators (icds); Ventricular arrhythmias

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Sudden cardiac death in children and young adults without structural heart disease: a comprehensive review
Takeshi Tsuda, Kristi K. Fitzgerald, Joel Temple
Reviews in Cardiovascular Medicine    2020, 21 (2): 205-216.   DOI: 10.31083/j.rcm.2020.02.55
Abstract832)   HTML94)    PDF(pc) (761KB)(1705)       Save
Sudden cardiac death (SCD) is a rare clinical encounter in pediatrics, but its social impact is immense because of its unpredicted and catastrophic nature in previously healthy individuals. Unlike in adults where the primary cause of SCD is related to ischemic heart disease, the etiology is diverse in young SCD victims. Although certain structural heart diseases may be identified during autopsy in some SCD victims, autopsy-negative SCD is more common in pediatrics, which warrants the diagnosis of sudden arrhythmic death syndrome (SADS) based upon the assumption that the usual heart rhythm is abruptly replaced by lethal ventricular arrhythmia. Despite current advances in molecular genetics, the causes of more than half of SADS cases remain unanswered even after postmortem genetic testing. Moreover, the majority of these deaths occur at rest or during sleep even in the young. Recently, sudden unexpected death in epilepsy (SUDEP) has emerged as another etiology of SCD in children and adults, suggesting critical involvement of the central nervous system (CNS) in SCD. Primary cardiac disorders may not be solely responsible for SCD; abnormal CNS function may also contribute to the unexpected lethal event. In this review article, we provide an overview of the complex pathogenesis of SADS and its diverse clinical presentation in the young and postulate that SADS is, in part, induced by unfortunate miscommunication between the heart and CNS via the autonomic nervous system.
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Sudden cardiac death: epidemiology, pathogenesis and management
Akshay Kumar, Dor Mordehay Avishay, Calvin Richard Jones, Juber Dastagir Shaikh, Roopvir Kaur, Michael Aljadah, Asim Kichloo, Nimisha Shiwalkar, Suresh Keshavamurthy
Reviews in Cardiovascular Medicine    2021, 22 (1): 147-158.   DOI: 10.31083/j.rcm.2021.01.207
Abstract549)   HTML103)    PDF(pc) (307KB)(963)       Save
Sudden cardiac death (SCD) is an unexpected sudden death due to a heart condition, that occurs within one hour of symptoms onset. SCD is a leading cause of death in western countries, and is responsible for the majority of deaths from cardiovascular disease. Moreover, SCD accounts for mortality in approximately half of all coronary heart disease patients. Nevertheless, the recent advancements made in screening, prevention, treatment, and management of the underlying causes has decreased this number. In this article, we sought to review established and new modes of screening patients at risk for SCD, treatment and prevention of SCD, and the role of new technologies in the field. Further, we delineate the current epidemiologic trends and pathogenesis. In particular, we describe the advancement in molecular autopsy and genetic testing, the role of target temperature management, extracorporeal membrane oxygenation (ECMO), cardiopulmonary resuscitation (CPR), and transvenous and subcutaneous implantable cardioverter devices (ICDs).
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