Special Issues

Special Issue Title: The technological innovations of the electrophysiological world: are we facing new frontiers of treatment for patients?

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· Deadline for manuscript submissions:  30 November 2021

Special Issue Editor

Guest Editor

        Prof. Matteo Bertini, MD, PhD

        Department of Translational Medicine, University of Ferrara, Italy

Website | E-Mail

Interests: Arrhythmias; Cardiac devices and ablation proceduresn

Special Issue Information

Dear Colleagues,

In 2021 we are facing several innovations in the field of electrophysiology which are also changing the management of our patients. Regarding the stimulation, we are observing: the increasing use of leadless pacemaker and recently we have also the opportunity to have a leadless VDD pacemaker; the physiologic pacing is becoming more and more popular involving not only His bundle pacing but also left bundle pacing. Focusing on tachyarrhythmias instead, zero-fluoroscopy, high density mapping, epicardial approach e new energy forms are coming out as important options to optimize the treatment.
This Special Issue will be focused on innovations in electrophysiological world, on the clinical relevance of novelties thus far acquired, and on the near future perspectives derived by the changing in the management of our patients.  

Prof. Matteo Bertini

Guest Editor


Manuscript Submission Information

Manuscripts should be submitted online at https://rcm.imrpress.org by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Reviews in Cardiovascular Medicine is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is $1950. Submitted papers should be well formatted and use good English.


Innovations; Leadless; Physiologic pacing; Zero-fluoro; High density mapping; Epicardial approach; New energy forms

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Medical therapy, radiofrequency ablation or cryoballoon ablation as first-line treatment for paroxysmal atrial fibrillation: interpreting efficacy through restricted mean survival time and network meta-analysis
Andrea Messori, Laura Bartoli, Elisa Ferracane, Sabrina Trippoli
Reviews in Cardiovascular Medicine    2021, 22 (3): 557-561.   DOI: 10.31083/j.rcm2203067
Abstract70)   HTML10)    PDF(pc) (957KB)(99)       Save
When multiple treatments are available, network meta-analysis can evaluate data to rank the relative effectiveness. We applied this approach to first-line treatments for paroxysmal atrial fibrillation (medical therapy, radiofrequency ablation or cryoballoon ablation). Individual trials were analysed based on the restricted mean survival time (RMST). Randomised controlled trials (RCT) assessing first-line treatments for paroxysmal atrial fibrillation were referenced from PubMed and the websites of regulatory agencies. The primary end-point was atrial fibrillation recurrence-free survival at 12 months. The treatments assessed for their relative effectiveness were medical therapy, radiofrequency ablation and cryoballoon ablation. Individual trials were examined based on RMST. A Bayesian network meta-analysis was conducted to comparatively evaluate these treatments. Five trials were included in the analysis: two compared radiofrequency with medical treatment and three cryoballoon ablation with medical treatment. The indirect comparison of radiofrequency ablation vs cryoballoon ablation was assessed in the absence of RCTs. Differences in RMST (with 95% credible intervals) were estimated for all binary comparisons (direct or indirect). Radiofrequency and cryoballoon ablation showed significantly increased effectiveness compared with medical treatment. In the indirect comparison, radiofrequency showed a non-significant advantage over cryoballoon ablation. The ranking of effectiveness was as follows: (1) radiofrequency; (2) cryoballoon ablation; (3) medical treatment. In conclusion, we found that radiofrequency was the most effective treatment for paroxysmal atrial fibrillation according to a Bayesian probabilistic model.
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