Special Issues

Special Issue Title: Coronary Artery Atherosclerosis: Translation from Basic to Clinic

· Print Special Issue Flyer

· Deadline for manuscript submissions: 30 March 2022

Special Issue Editor

Guest Editor

Dr. Gianluca Rigatelli

Cardiovascular Diagnosis and Endoluminal Interventions, Rovigo General Hospital, Viale Tre Martiri, Rovigo, Italy

Website  | E-Mail1 | E-Mail2

InterestsTranscatheter congenital interventions; Coronary anomalies pathophysiology; Left main coronary artery bifurcation physiology and stenting

Dr. Marco Zuin

Department of Translational Medicine, University of Ferrara, Ferrara, Italy

Website | E-Mail

InterestsCardiology; Internal medicine; Computational; Statistics

Special Issue Information

Dear Colleagues,

Coronary atherosclerosis is one of the leading cause of death in developed countries and one of the most investigated fields in cardiovascular medicine accounting for a huge part of the cost of health systems all over the world. Understanding pathophysiology is heavily linked to the chance of preventing or treat the clinical manifestations of coronary artery disease. New hypotheses and insights from basic science and medicine are currently been investigated or are in the pipeline to be translated into clinical practice. Basic science investigations about the contribution of new markers of disease to development of clinical apparent atherosclerosis are being undertaken in the most advanced centers. Computational and virtual simulation medicine is taking part as one of the newest tools in understanding pathophysiology of the atherosclerotic process and predicting fate of available endovascular therapy. At the same time, new drugs new imaging tools and new interventional techniques and protocols are being developed in order to improve diagnosis, clinical outcomes and prognosis of coronary atherosclerosis. The new special issues of Reviews in Cardiovascular Medicine (ISSN 1530-6550) is aimed to explore this exciting process of translation from basic science to clinical practice in the knowledge, diagnosis and treatment of coronary atherosclerosis.

Dr. Gianluca Rigatelli and Dr. Marco Zuin

Guest Editors


Manuscript Submission Information

Manuscripts should be submitted online at https://rcm.imrpress.org by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Reviews in Cardiovascular Medicine is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is $1950. Submitted papers should be well formatted and use good English.


Coronary artery; Atherosclerosis; Basic science; Therapy; Interventional; Prevention; Pathophysiology

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Trimethylamine N-oxide—a marker for atherosclerotic vascular disease
Guinan Xie, An Yan, Peng Lin, Yi Wang, Liping Guo
Reviews in Cardiovascular Medicine    2021, 22 (3): 787-797.   DOI: 10.31083/j.rcm2203085
Abstract118)   HTML9)    PDF(pc) (469KB)(680)       Save
As a potential causative factor in various cardiovascular diseases, the gut microbe-generated metabolite trimethylamine N-oxide (TMAO) has courted considerable research interest as a potential biomarker. TMAO is a small molecule considered to be beneficial for the health of deep-water animals due to its ability to protect proteins against hydrostatic pressure stress. However, it may cause deleterious effects in humans as mounting evidence suggests that TMAO may enhance atherosclerosis, independent of traditional risk factors. This may be mediated by its capacity to enhance inflammation, platelet activation and thrombosis, and inhibit reverse cholesterol transport. In humans, circulating levels of TMAO have been found to be associated with increased risk of developing atherosclerotic diseases such as carotid atherosclerosis, coronary atherosclerotic heart disease, stroke, and peripheral arteriosclerosis. This review aims to discuss the current role of TMAO in the atherosclerosis process, using animal models and clinical studies, with special attention to determining whether TMAO could be used as a marker for monitoring severity and prognosis in atherosclerosis and to evaluate evidence for its role as a mediator in the pathogenesis of atherosclerotic vascular disease.
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