Special Issues

Special Issue Title: Risk Factors for Cardiovascular Diseases

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· Deadline for manuscript submissions: 28 February 2022

Special Issue Editor

Guest Editor

Prof. Ichiro Wakabayashi

Dept. of Environmental & Preventive Medicine Hyogo College of Medicine Hyogo 663-8501, Japan

Website | E-Mail

InterestsAlcohol medicine; Cardiovascular epidemiology; MicroRNAs; Peptide biomarkers; Vascular biology

Prof. Klaus Groschner

Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging Medical University of Graz Graz 8010, Austria

Website | E-Mail

InterestsCa2+ signaling; Cardiovascular ion channels; TRPC channels; Membrane lipids; Lipid protein interactions

Special Issue Information

Dear Colleagues,

Evaluation of the risk of cardiovascular disease and its early prevention are essential for reduction of mortality and morbidity in industrialized communities. Age, gender, ethnicity and genetic predisposition are uncontrollable risk factors for cardiovascular disease. Hypertension, dyslipidemia, smoking and diabetes are the four major cardiovascular risk factors, which are correctable through medication therapy as well as improvement of lifestyles. These risk factors accelerate the progression of atherosclerosis, which is the most important pathogenesis of cardiovascular disease. Obesity, especially visceral obesity, is a central cardiovascular risk factor, and the cardiovascular risk is greatly increased in persons with metabolic syndrome, a status of accumulation of these risk factors. Hyperuricemia and chronic kidney disease are directly and indirectly (through other risk factors) associated with cardiovascular disease. In addition to the aforementioned classical risk factors, elevated circulating homocysteine and acute-phase protein concentrations have been shown to be cardiovascular risk factors. It has been an issue of debate whether elevation of acute-phase proteins reflecting chronic inflammation is a cause, consequence or both for the pathogenesis of cardiovascular disorders. The reason for the French paradox, meaning a prominently lower mortality from cardiovascular disease in France among Western countries, also remains to be elucidated, although a high consumption level of red wine in France and the antioxidative action through polyphenols contained in red wine have been proposed as the basis for the French paradox. Low cardiovascular mortality is also known in eastern Asian countries, although the lifestyles including diet in eastern Asian countries are becoming similar to those in western countries. Since 2020, the most important health-related worldwide topic is undoubtedly the pandemic of Covid-19. Cardiovascular risk factors including hypertension, obesity and diabetes are known to be exacerbating factors for the disease stage of Covid-19 infection. 
In this special issue, we would like to introduce recent topics on cardiovascular risk factors broadly. Articles focusing not only on epidemiological studies but also on experimental studies are welcome to this issue. We are hoping that this issue will prepare the ground for the development of future strategies for promotion of cardiovascular health and prevention of cardiovascular aging and dysfunction.

Prof. Ichiro Wakabayashi and Prof. Klaus Groschner

Guest Editors


Manuscript Submission Information

Manuscripts should be submitted online at https://rcm.imrpress.org by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Reviews in Cardiovascular Medicine is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is $1950. Submitted papers should be well formatted and use good English.


Aging; Atherosclerosis; Diabetes mellitus; Dyslipidemia; Hypertension; Metabolic syndrome; Obesity; Smoking

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The blooming intersection of subfatin and metabolic syndrome
Shenglei Huang, Lei Cao, Hongwei Cheng, Dongliang Li, Yi Li, Zhixian Wu
Reviews in Cardiovascular Medicine    2021, 22 (3): 799-805.   DOI: 10.31083/j.rcm2203086
Abstract83)   HTML8)    PDF(pc) (370KB)(235)       Save
Metabolic Syndrome (MS) remains the leading cause of mortality and morbidity globally. Adipose tissue releases adipokines that play key roles in metabolic and cardio-cerebro-vascular homeostasis. Subfatin, induced after exercise or upon cold exposure in adipose tissue, is a novel secreted protein homologous to Metrn, a neutrophic factor with angiogenic properties. The protein was proved to be of great significance in the browning of white adipose tissue (BWT) and insulin resistance (IR). It affected insulin sensitivity at least via its local autocrine/paracrine action through AMP-activated protein kinase (AMPK) or peroxisome proliferator-activated receptor δ (PPAR-δ) dependent signaling. Subfatin blocked the release of inflammatory mediators, improved intracellular insulin signal transduction and reversed IR. It also improved glucose tolerance and played a key role in metabolism and cardiovascular and cerebrovascular homeostasis. It was reported that the level of serum subfatin was significantly correlated with the occurrence and severity of coronary heart disease, which might be a new target for the treatment of coronary heart disease. In addition, exercise increased the level of subfatin in circulation and adipose tissue, promoted energy consumption, improved glucose and lipid metabolism, increased the heat production of brown fat, and strengthened the anti-inflammatory mechanism. Given its role in metabolic disorders, subfatin is considered as a candidate biomarker of MS. However, the clinical significance of subfatin remains largely unclear. The purpose of this article is to review the research on the effect of subfatin on MS in recent years.
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